ArticleClinical journal of the American Society of Nephrology : CJASN2012
Modifiable practices associated with sudden death among hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04563091 (Development of a Mathematical Model for the Evaluation of the Potassium Kinetic During and After Hemodialysis for the Potassium Profiling in the Dialysate to Prevent Arrhythmias), which is not on this map. Cited by 78 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development of a Mathematical Model for the Evaluation of the Potassium Kinetic During and After Hemodialysis for the Potassium Profiling in the Dialysate to Prevent Arrhythmias
Who cites it
78 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The effect of hyperkalemia and long inter-dialytic interval on morbidity and mortality in patients receiving hemodialysis: a systematic review.Renal failure · 2021Pooled it
- Renal Association Clinical Practice Guideline on Haemodialysis.BMC nephrology · 2019Guideline
- Incidence of sudden cardiac death in adults with end-stage renal disease: a systematic review and meta-analysis.BMC nephrology · 2016Pooled it
- Twice against thrice-weekly hemodialysis (TATH): a multicenter nonrandomized trial.BMC nephrology · 2025Trial
- Cause-Specific Mortality in Patients With Advanced Chronic Kidney Disease in the ISCHEMIA-CKD Trial.JACC. Cardiovascular interventions · 2023Trial
- Potassium responses to sodium zirconium cyclosilicate in hyperkalemic hemodialysis patients: post-hoc analysis of DIALIZE.BMC nephrology · 2022Trial
- Oral sodium bicarbonate in people on haemodialysis: a randomised controlled trial.BMC nephrology · 2021Trial
- A Phase 3b, Randomized, Double-Blind, Placebo-Controlled Study of Sodium Zirconium Cyclosilicate for Reducing the Incidence of Predialysis Hyperkalemia.Journal of the American Society of Nephrology : JASN · 2019Trial
- Relationship between dialytic parameters and reviewer confirmed arrhythmias in hemodialysis patients in the monitoring in dialysis study.BMC nephrology · 2019Trial
- Lifesaving power of preparedness in dialysis units.Kidney research and clinical practice · 2026Article
- Effect of preparedness of emergency equipment on patient survival in hemodialysis facilities: a Korean nationwide cohort study.Kidney research and clinical practice · 2026Article
- Real-world effectiveness of patiromer among hemodialysis patients: a one-year retrospective cohort study.BMC nephrology · 2026Article
- QT-prolonging medications: prevalence of use and associated risks in CKD.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Review
- Relationship Between Timing of Hemodialysis and Procedure-Related Complications Following Endoscopy in Patients with End-Stage Renal Disease.Digestive diseases and sciences · 2025Article
- The association between systolic and diastolic dysfunction and autonomic nervous system function in children receiving chronic hemodialysis.Pediatric nephrology (Berlin, Germany) · 2025Observational
- Article
- Type of arrhythmias and the risk of sudden cardiac death in dialysis patients: a systematic review and meta-analysis.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025Review
- The Impact of Potassium Dynamics on Cardiomyocyte Beating in Hemodialysis Treatment.Journal of clinical medicine · 2024Article
- Semaglutide and Patients Receiving Hemodialysis: Case Reports of Unexpected Benefits for Hyperphosphatemia and Hyperkalemia.The Canadian journal of hospital pharmacy · 2024Article
- Personalizing electrolytes in the dialysis prescription: what, why and how?Clinical kidney journal · 2024Review
18 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors.
Funding
Abstract
BACKGROUND AND
objectivesSudden death is common in hemodialysis patients, but whether modifiable practices affect the risk of sudden death remains unclear. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This study analyzed 37,765 participants in 12 countries in the Dialysis Outcomes and Practice Patterns Study to explore the association of the following practices with sudden death (due to cardiac arrhythmia, cardiac arrest, and/or hyperkalemia): treatment time [TT] <210 minutes, Kt/V <1.2, ultrafiltration volume >5.7% of postdialysis weight, low dialysate potassium [K(D) <3]), and prescription of Q wave/T wave interval-prolonging drugs. Cox regression was used to estimate effects on mortality, adjusting for potential confounders. An instrumental variable approach was used to further control for unmeasured patient-level confounding.
resultsThere were 9046 deaths, 26% of which were sudden (crude mortality rate, 15.3/100 patient-years; median follow-up, 1.59 years). Associations with sudden death included hazard ratios of 1.13 for short TT, 1.15 for large ultrafiltration volume, and 1.10 for low Kt/V. Compared with K(D) ≥3 mEq/L, the sudden death rate was higher for K(D) ≤1.5 and K(D)=2-2.5 mEq/L. The instrumental variable approach yielded generally consistent findings. The sudden death rate was elevated for patients taking amiodarone, but not other Q wave/T wave interval-prolonging drugs.
conclusionsThis study identified modifiable dialysis practices associated with higher risk of sudden death, including short TT, large ultrafiltration volume, and low K(D). Because K(D) <3 mEq/L is common and easy to change, K(D) tailoring may prevent some sudden deaths. This hypothesis merits testing in clinical trials.
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