ArticleToxicological sciences : an official journal of the Society of Toxicology2012
Irritancy and allergic responses induced by exposure to the indoor air chemical 4-oxopentanal.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 79 citations in OpenAlex.
- Influence of Ventilation Rate and Indoor Air Mixing on Ozone-Human Skin Chemistry.ACS ES&T air · 2026Article
- Insights into Dermal Permeation of Skin Oil Oxidation Products from Enhanced Sampling Molecular Dynamics Simulation.The journal of physical chemistry. B · 2025Article
- Emissions of Volatile Organic Compounds from Human Occupants in a Student Office: Dependence on Ozone Concentration.ACS environmental Au · 2024Article
- Reactions and Products of Squalene and Ozone: A Review.Environmental science & technology · 2022Review
- Emission Rates of Volatile Organic Compounds from Humans.Environmental science & technology · 2022Article
- Effect of Ozone, Clothing, Temperature, and Humidity on the Total OH Reactivity Emitted from Humans.Environmental science & technology · 2021Article
- Large-Format Additive Manufacturing and Machining Using High-Melt-Temperature Polymers. Part II: Characterization of Particles and Gases.Journal of chemical health & safety · 2021Article
- Observing ozone chemistry in an occupied residence.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Review of NIOSH Cannabis-Related Health Hazard Evaluations and Research.Annals of work exposures and health · 2020Article
- Indoor ozone/human chemistry and ventilation strategies.Indoor air · 2019Article
- Exposure Assessment For Air-To-Skin Uptake of Semivolatile Organic Compounds (SVOCs) Indoors.Environmental science & technology · 2019Article
- Three-dimensional printing with nano-enabled filaments releases polymer particles containing carbon nanotubes into air.Indoor air · 2018Article
- Exposure to selected limonene oxidation products: 4-OPA, IPOH, 4-AMCH induces oxidative stress and inflammation in human lung epithelial cell lines.Chemosphere · 2018Article
- Identification and quantification of carbonyl-containing α-pinene ozonolysis products usingJournal of atmospheric chemistry · 2017Article
- Characterization of chemical contaminants generated by a desktop fused deposition modeling 3-dimensional Printer.Journal of occupational and environmental hygiene · 2017Article
- Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants.Environmental science & technology · 2017Article
- A Role for Regulatory T Cells in a Murine Model of Epicutaneous Toluene Diisocyanate Sensitization.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- Subchronic exposures to fungal bioaerosols promotes allergic pulmonary inflammation in naïve mice.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2016Article
- Volatile organic compound conversion by ozone, hydroxyl radicals, and nitrate radicals in residential indoor air: Magnitudes and impacts of oxidant sources.Atmospheric environment (Oxford, England : 1994) · 2015Article
- Impact of cabin ozone concentrations on passenger reported symptoms in commercial aircraft.PloS one · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Over the last two decades, there has been an increasing awareness regarding the potential impact of indoor air pollution on human health. People working in an indoor environment often experience symptoms such as eye, nose, and throat irritation. Investigations into these complaints have ascribed the effects, in part, to compounds emitted from building materials, cleaning/consumer products, and indoor chemistry. One suspect indoor air contaminant that has been identified is the dicarbonyl 4-oxopentanal (4-OPA). 4-OPA is generated through the ozonolysis of squalene and several high-volume production compounds that are commonly found indoors. Following preliminary workplace sampling that identified the presence of 4-OPA, these studies examined the inflammatory and allergic responses to 4-OPA following both dermal and pulmonary exposure using a murine model. 4-OPA was tested in a combined local lymph node assay and identified to be an irritant and sensitizer. A Th1-mediated hypersensitivity response was supported by a positive response in the mouse ear swelling test. Pulmonary exposure to 4-OPA caused a significant elevation in nonspecific airway hyperreactivity, increased numbers of lung-associated lymphocytes and neutrophils, and increased interferon-γ production by lung-associated lymph nodes. These results suggest that both dermal and pulmonary exposure to 4-OPA may elicit irritant and allergic responses and may help to explain some of the adverse health effects associated with poor indoor air quality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.