ArticleToxicological sciences : an official journal of the Society of Toxicology2012
Sensitivity to dioxin decreases as zebrafish mature.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Zebrafish Congenital Heart Disease Models: Opportunities and Challenges.International journal of molecular sciences · 2024Review
- Environmentally relevant uptake, elimination, and metabolic changes following early embryonic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in zebrafish.Chemosphere · 2023Article
- Dioxin Disrupts Dynamic DNA Methylation Patterns in Genes That Govern Cardiomyocyte Maturation.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Mechanisms of Developmental Toxicity of Dioxins and Related Compounds.International journal of molecular sciences · 2019Review
- Teratological and Behavioral Screening of the National Toxicology Program 91-Compound Library in Zebrafish (Danio rerio).Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Ancestral TCDD Exposure Induces Multigenerational Histologic and Transcriptomic Alterations in Gonads of Male Zebrafish.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Disruption of Nuclear Receptor Signaling Alters Triphenyl Phosphate-Induced Cardiotoxicity in Zebrafish Embryos.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Ah Receptor Activation by Dioxin Disrupts Activin, BMP, and WNT Signals During the Early Differentiation of Mouse Embryonic Stem Cells and Inhibits Cardiomyocyte Functions.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- Generation of Tg(cyp1a:gfp) Transgenic Zebrafish for Development of a Convenient and Sensitive In Vivo Assay for Aryl Hydrocarbon Receptor Activity.Marine biotechnology (New York, N.Y.) · 2015Article
- Dioxin inhibition of swim bladder development in zebrafish: is it secondary to heart failure?Aquatic toxicology (Amsterdam, Netherlands) · 2015Article
- Histopathologic alterations associated with global gene expression due to chronic dietary TCDD exposure in juvenile zebrafish.PloS one · 2014Article
- Early dioxin exposure causes toxic effects in adult zebrafish.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Sox9b is required for epicardium formation and plays a role in TCDD-induced heart malformation in zebrafish.Molecular pharmacology · 2013Article
- Epicardium Formation as a Sensor in Toxicology.Journal of developmental biology · 2013Article
- Statistically enhanced spectral counting approach to TCDD cardiac toxicity in the adult zebrafish heart.Journal of proteome research · 2013Article
- TCDD inhibits heart regeneration in adult zebrafish.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Dioxin inhibits zebrafish epicardium and proepicardium development.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Reproductive and developmental toxicity of dioxin in fish.Molecular and cellular endocrinology · 2012Review
- Adverse effects in adulthood resulting from low-level dioxin exposure in juvenile zebrafish.Endocrine disruptors (Austin, Tex.)Article
- Disruption of aryl hydrocarbon receptor homeostatic levels during embryonic stem cell differentiation alters expression of homeobox transcription factors that control cardiomyogenesis.Environmental health perspectivesArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The embryos of teleost fish are exquisitely sensitive to the toxic effects of exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). However, several lines of evidence suggest that adults are less sensitive to TCDD. To better understand and characterize this difference between early life stage and adults, we exposed zebrafish (Danio rerio) to graded TCDD concentrations at different ages. The LD(50) for embryos exposed at 1 day post-fertilization (dpf) was more than an order of magnitude lower than it was for juveniles exposed at 30 dpf. The latency between exposure and response also increased with age. Embryo toxicity was characterized by marked cardiovascular collapse and heart malformation, whereas juveniles exposed at 30 dpf had no detectable cardiovascular toxicity. In juveniles, the effects of TCDD exposure included stunted growth, altered pigmentation, and skeletal malformations. Furthermore, the transcriptional profile produced in hearts exposed to TCDD as embryos had very little overlap with the transcriptional changes induced by TCDD at 30 dpf. The early cardiotoxic response was associated with fish exposed prior to metamorphosis from the larval to the adult body plan at approximately 14 dpf. Our results show conclusively that the developmental stage at the time of exposure controls the toxic response to TCDD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.