ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2012
Aging does not reduce heat shock protein 70 in the absence of chronic insulin resistance.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Association of Primate Veterinarians Guidelines for Weight Management in Research Nonhuman Primates.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Effects of resistance training on heat shock response (HSR), HSP70 expression, oxidative stress, inflammation, and metabolism in middle-aged people.Journal of physiology and biochemistry · 2024Article
- Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet.BMC genomics · 2021Article
- Alfalfa-derived HSP70 administered intranasally improves insulin sensitivity in mice.Cell stress & chaperones · 2018Article
- Exercise, heat shock proteins and insulin resistance.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Regulators of mitochondrial quality control differ in subcutaneous fat of metabolically healthy and unhealthy obese monkeys.Obesity (Silver Spring, Md.) · 2017Article
- Deficiency in the Heat Stress Response Could Underlie Susceptibility to Metabolic Disease.Diabetes · 2016Article
- Effects of heated hydrotherapy on muscle HSP70 and glucose metabolism in old and young vervet monkeys.Cell stress & chaperones · 2016Article
- Oral supplementations with L-glutamine or L-alanyl-L-glutamine do not change metabolic alterations induced by long-term high-fat diet in the B6.129F2/J mouse model of insulin resistance.Molecular and cellular biochemistry · 2016Article
- Inducing Muscle Heat Shock Protein 70 Improves Insulin Sensitivity and Muscular Performance in Aged Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Muscle heat shock protein 70 predicts insulin resistance with aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- The importance of the cellular stress response in the pathogenesis and treatment of type 2 diabetes.Cell stress & chaperones · 2014Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Heat shock protein (HSP)70 decreases with age. Often aging is associated with coincident insulin resistance and higher blood glucose levels, which also associate with lower HSP70. We aimed to understand how these factors interrelate through a series of experiments using vervet monkeys (Chlorocebus aethiops sabaeous). Monkeys (n = 284, 4-25 years) fed low-fat diets showed no association of muscle HSP70 with age (r = .04, p = .53), but levels were highly heritable. Insulin resistance was induced in vervet monkeys with high-fat diets, and muscle biopsies were taken after 0.3 or 6 years. HSP70 levels were significantly greater after 0.3 years (+72%, p < .05) but were significantly lower following 6 years of high-fat diet (-77%, p < .05). Associations with glucose also switched from being positive (r = .44, p = .03) to strikingly negative (r = -.84, p < .001) with increasing insulin resistance. In conclusion, a low-fat diet may preserve tissue HSP70 and health with aging, whereas high-fat diets, insulin resistance, and genetic factors may be more important than age for determining HSP70 levels.
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