ArticleGenome biology and evolution2012
Identification and properties of 1,119 candidate lincRNA loci in the Drosophila melanogaster genome.
Article in Genome biology and evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers.
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Who cites it
119 citing papers in PubMed, 222 citations in OpenAlex.
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- Characterization of full-length long noncoding RNAs and identification of virus-responsive lncRNAs inFrontiers in microbiology · 2025Article
- Identification and Functional Analysis of Novel Long Intergenic RNA in Chicken Macrophages Infected with Avian PathogenicMicroorganisms · 2024Article
- siRNAs Targeting Non-Human Species-Specific lncRNAs Trigger Cell Death in Human Colorectal Cancer Cells.Journal of Cancer · 2024Article
- The pleiotropic functions of Pri smORF peptides synchronize leg development regulators.PLoS genetics · 2023Article
- Recent Advances and Future Potential of Long Non-Coding RNAs in Insects.International journal of molecular sciences · 2023Review
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- Genomic and functional conservation of lncRNAs: lessons from flies.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Review
- Emerging role of non-coding RNA in health and disease.Metabolic brain disease · 2021Review
- Transcriptome analysis reveals potential function of long non-coding RNAs in 20-hydroxyecdysone regulated autophagy in Bombyx mori.BMC genomics · 2021Article
- Systematic and computational identification of Androctonus crassicauda long non-coding RNAs.Scientific reports · 2021Article
- Review
- The landscape of lncRNAs in Cydia pomonella provides insights into their signatures and potential roles in transcriptional regulation.BMC genomics · 2021Article
- An integrative proteogenomics approach reveals peptides encoded by annotated lincRNA in the mouse kidney inner medulla.Physiological genomics · 2020Article
- Characterization and analysis of full-length transcriptomes from two grasshoppers, Gomphocerus licenti and Mongolotettix japonicus.Scientific reports · 2020Article
- Long non-coding RNAs in development and disease: conservation to mechanisms.The Journal of pathology · 2020Review
- Comprehensive Identification and Characterization of Long Non-coding RNAs Associated With Rice Black-Streaked Dwarf Virus Infection inFrontiers in physiology · 2020Article
59 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The functional repertoire of long intergenic noncoding RNA (lincRNA) molecules has begun to be elucidated in mammals. Determining the biological relevance and potential gene regulatory mechanisms of these enigmatic molecules would be expedited in a more tractable model organism, such as Drosophila melanogaster. To this end, we defined a set of 1,119 putative lincRNA genes in D. melanogaster using modENCODE whole transcriptome (RNA-seq) data. A large majority (1.1 of 1.3 Mb; 85%) of these bases were not previously reported by modENCODE as being transcribed. Significant selective constraint on the sequences of these loci predicts that virtually all have sustained functionality across the Drosophila clade. We observe biases in lincRNA genomic locations and expression profiles that are consistent with some of these lincRNAs being involved in the regulation of neighboring protein-coding genes with developmental functions. We identify lincRNAs that may be important in the developing nervous system and in male-specific organs, such as the testes. LincRNA loci were also identified whose positions, relative to nearby protein-coding loci, are equivalent between D. melanogaster and mouse. This study predicts that the genomes of not only vertebrates, such as mammals, but also an invertebrate (fruit fly) harbor large numbers of lincRNA loci. Our findings now permit exploitation of Drosophila genetics for the investigation of lincRNA mechanisms, including lincRNAs with potential functional analogues in mammals.
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Registered trials
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