ArticleInternational journal of legal medicine2013
Chimerism in DNA of buccal swabs from recipients after allogeneic hematopoietic stem cell transplantations: implications for forensic DNA testing.
Article in International journal of legal medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Who Am I? Eyebrow Follicles Minimize Donor-Derived DNA for Germline Testing After Hematopoietic Stem Cell Transplantation.International journal of molecular sciences · 2026Article
- Beyond the Blood Cell: The Emerging Role of Cell-Free DNA in Transfusion Medicine.Journal of hematology · 2025Review
- Hereditary Hematopoietic Malignancies: Considerations for Optimizing Diagnosis and Management.Current oncology reports · 2025Review
- A prenatal case misunderstood as specimen confusion: 46,XY/46,XY chimerism.BMC pregnancy and childbirth · 2024Article
- Incidental detection of acquired variants in germline genetic and genomic testing: a points to consider statement of the American College of Medical Genetics and Genomics (ACMG).Genetics in medicine : official journal of the American College of Medical Genetics · 2021Article
- A case of 46,XX/46,XX chimerism in a phenotypically normal woman.International journal of legal medicine · 2020Article
- Evaluation of blood, buccal swabs, and hair follicles for DNA profiling technique using STR markers.Croatian medical journal · 2015Article
- Serotonin transporter genotype (5-HTTLPR) and electrocortical responses indicating the sensitivity to negative emotional cues.Emotion (Washington, D.C.) · 2013Article
- Comparison of morphological and molecular genetic sex-typing on mediaeval human skeletal remains.Forensic science international. Genetics · 2013Article
- Genetic investigation of biological materials from patients after stem cell transplantation based on autosomal as well as Y-chromosomal markers.International journal of legal medicine · 2013Article
- Molecular genetic investigations on Austria's patron saint Leopold III.Forensic science international. Genetics · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We attempted to quantitatively determine the chimeric state in a total of 162 buccal swabs from 77 adult recipients aged 19-74 (median 50 years) after allogeneic hematopoietic cell transplantation by estimating the chimeric recipient/donor DNA ratios through analysis of 15 autosomal short tandem repeat markers. From each individual between one and nine, buccal swabs were taken at known time intervals after transplantation, ranging from 17 to 3,361 days (median 394 days). In buccal cells, the determined recipient/donor DNA ratios turned out to be highly variable between individuals and also within an individual. Relative donor chimerism levels (%Ch) between 0 and 100 % were detected with maximal frequencies between 10 and 30 %. Blood was always found to show the donor's genotype while hair samples in all cases gave the recipient's genotype. We examine chimerism levels with respect to age, gender, and posttransplantation period and discuss the results in the context of forensic identity testing.
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