ArticleCellular and molecular neurobiology2012
Stress stimulates production of catecholamines in rat adipocytes.
Article in Cellular and molecular neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Critical illness induces nutrient-independent adipogenesis and accumulation of alternatively activated tissue macrophages.Critical care (London, England) · 2013Trial
- Phenotypic and functional disparities in perivascular adipose tissue.Frontiers in physiology · 2024Review
- Protective role of perivascular adipose tissue in the cardiovascular system.Frontiers in endocrinology · 2023Review
- Prior Repeated Stress Attenuates Cold-Induced Immunomodulation Associated with "Browning" in Mesenteric Fat of Rats.Cellular and molecular neurobiology · 2018Article
- New actions of an old friend: perivascular adipose tissue's adrenergic mechanisms.British journal of pharmacology · 2017Review
- βInternational journal of medical sciences · 2017Article
- Specific features of adaptation of rats to chronic cold treatment.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2016Article
- Changes in levels of angiotensin II and its receptors in a model of inverted stress-induced cardiomyopathy.European journal of medical research · 2014Article
- Perivascular adipose tissue contains functional catecholamines.Pharmacology research & perspectives · 2014Article
- Intrinsic vascular dopamine - a key modulator of hypoxia-induced vasodilatation in splanchnic vessels.The Journal of physiology · 2014Article
- Stress: Neurobiology, consequences and management.Journal of pharmacy & bioallied sciences · 2013Article
- The role of "mixed" orexigenic and anorexigenic signals and autoantibodies reacting with appetite-regulating neuropeptides and peptides of the adipose tissue-gut-brain axis: relevance to food intake and nutritional status in patients with anorexia nervosa and bulimia nervosa.International journal of endocrinology · 2013Review
- Maternal high-fat diet induces obesity and adrenal and thyroid dysfunction in male rat offspring at weaning.The Journal of physiology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
The sympathoadrenal system is the main source of catecholamines (CAs) in adipose tissues and therefore plays the key role in the regulation of adipose tissue metabolism. We recently reported existence of an alternative CA-producing system directly in adipose tissue cells, and here we investigated effect of various stressors-physical (cold) and emotional stress (immobilization) on dynamics of this system. Acute or chronic cold exposure increased intracellular norepinephrine (NE) and epinephrine (EPI) concentration in isolated rat mesenteric adipocytes. Gene expression of CA biosynthetic enzymes did not change in adipocytes but was increased in stromal vascular fraction (SVF) after 28 day cold. Exposure of rats to a single IMO stress caused increases in NE and EPI levels, and also gene expression of CA biosynthetic enzymes in adipocytes. In SVF changes were similar but more pronounced. Animals adapted to a long-term cold exposure (28 days, 4°C) did not show those responses found after a single IMO stress either in adipocytes or SVF. Our data indicate that gene machinery accommodated in adipocytes, which is able to synthesize NE and EPI de novo, is significantly activated by stress. Cold-adapted animals keep their adaptation even after an exposure to a novel stressor. These findings suggest the functionality of CAs produced endogenously in adipocytes. Taken together, the newly discovered CA synthesizing system in adipocytes is activated in stress situations and might significantly contribute to regulation of lipolysis and other metabolic or thermogenetic processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.