SynthesisInflammation research : official journal of the European Histamine Research Society ... [et al.]2012
Associations between TNFAIP3 gene polymorphisms and rheumatoid arthritis: a meta-analysis.
Synthesis in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Vitamin D receptor (VDR) gene polymorphism and risk of rheumatoid arthritis (RA): systematic review and meta-analysis.Clinical rheumatology · 2020Pooled it
- Association between plasminogen activator inhibitor‑1 (PAI-1) 4G/5G polymorphism and circulating PAI-1 level in systemic lupus erythematosus and rheumatoid arthritis : A meta-analysis.Zeitschrift fur Rheumatologie · 2020Pooled it
- Three single nucleotide polymorphisms of TNFAIP3 gene increase the risk of rheumatoid arthritis.Oncotarget · 2017Pooled it
- TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of rheumatoid arthritis.Oncotarget · 2016Pooled it
- Genetic Variations inGenes · 2026Article
- Analysis of TNFAIP3, IRAK1, and TLR4 Gene Polymorphisms in Patients With Rheumatoid Arthritis.Immunity, inflammation and disease · 2026Article
- Neutrophils: a Central Point of Interaction Between Immune Cells and Nonimmune Cells in Rheumatoid Arthritis.Clinical reviews in allergy & immunology · 2025Review
- Article
- Single Nucleotide Polymorphisms Associated with Rheumatoid Arthritis in Saudi Patients.Journal of clinical medicine · 2023Article
- Relative efficacy and safety of Janus kinase inhibitors for the treatment of active psoriatic arthritis: a network meta-analysis.Zeitschrift fur Rheumatologie · 2023Article
- Comparative efficacy and safety of infliximab and its biosimilars in patients with rheumatoid arthritis presenting an insufficient response to methotrexate : A network meta-analysis.Zeitschrift fur Rheumatologie · 2023Article
- Article
- Janus kinase inhibitors for treating active ankylosing spondylitis: a meta-analysis of randomized controlled trials.Zeitschrift fur Rheumatologie · 2022Article
- Comparative study of the efficacy and safety of tofacitinib, baricitinib, upadacitinib, and filgotinib versus methotrexate for disease-modifying antirheumatic drug-naïve patients with rheumatoid arthritis.Zeitschrift fur Rheumatologie · 2021Article
- Comparative efficacy and safety of tofacitinib, baricitinib, upadacitinib, and filgotinib in active rheumatoid arthritis refractory to biologic disease-modifying antirheumatic drugs.Zeitschrift fur Rheumatologie · 2021Article
- Single nucleotide polymorphism rs5029937 in TNFAIP3 gene is correlated with risk of rheumatoid arthritis.Medical journal of the Islamic Republic of Iran · 2021Article
- The PANoptosome: A Deadly Protein Complex Driving Pyroptosis, Apoptosis, and Necroptosis (PANoptosis).Frontiers in cellular and infection microbiology · 2020Review
- Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus.Annals of the rheumatic diseases · 2019Article
- Article
- Novel Heterogeneous Mutation of TNFAIP3 in a Chinese Patient with Behçet-Like Phenotype and Persistent EBV Viremia.Journal of clinical immunology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to determine whether tumor necrosis factor alpha inducible protein 3 (TNFAIP3) polymorphisms confer susceptibility to rheumatoid arthritis (RA) in ethnically different populations.
methodsThe authors conducted meta-analyses on associations between the TNFAIP3 polymorphisms and RA susceptibility.
resultA total of ten comparative studies were included in this meta-analysis, which showed an association between the two allele of rs6920220 and RA in all study subjects [odds ratio (OR) 1.216, 95% confidence interval (CI) 1.166-1.269, p < 1.0 × 10(-9)]. The two allele of rs6920220 was also significantly associated with RA in Europeans only (OR 1.227, 95% CI 1.175-1.282, p < 1.0 × 10(-9)). Meta-analysis revealed no association between the two allele of the rs10499194 polymorphism and RA in Europeans, but a significant association was found in Asians (OR 1.254, 95% CI 1.101-1.429, p=6.7 × 10(-4)). Furthermore, an association was found between the two allele of rs2230926 and RA in all study subjects (OR 1.390, 95% CI 1.214-2.331, p=1.9 × 10(-6)).
conclusionsThis meta-analysis confirms that the TNFAIP3 polymorphisms are associated with RA susceptibility in different ethnic groups, namely, in Europeans for rs6920220 and in Asians for rs10499194.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.