ArticleCell death & disease2012
IGL-1 solution reduces endoplasmic reticulum stress and apoptosis in rat liver transplantation.
Article in Cell death & disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Multi-compartment profiling of donor-derived microRNAs during liver graft procurement: a prospective feasibility study.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Expert Consensus on the Diagnosis and Management of Carotid Atherosclerotic Plaque: Pathophysiology, Clinical Management, and Preventive Approaches.International journal of medical sciences · 2025Review
- Review
- Role of Mitochondrial Pathways in Cell Apoptosis during He-Patic Ischemia/Reperfusion Injury.International journal of molecular sciences · 2022Review
- Metabotropic Glutamate Receptor Blockade Reduces Preservation Damage in Livers from Donors after Cardiac Death.International journal of molecular sciences · 2021Article
- Liver graft preservation methods during cold ischemia phase and normothermic machine perfusion.World journal of gastrointestinal surgery · 2019Review
- Relevance of proteolysis and proteasome activation in fatty liver graft preservation: An Institut Georges Lopez-1World journal of gastroenterology · 2017Article
- GSK3β and VDAC Involvement in ER Stress and Apoptosis Modulation during Orthotopic Liver Transplantation.International journal of molecular sciences · 2017Article
- Adiponectin protects the rats liver against chronic intermittent hypoxia induced injury through AMP-activated protein kinase pathway.Scientific reports · 2016Article
- Melatonin role preventing steatohepatitis and improving liver transplantation results.Cellular and molecular life sciences : CMLS · 2016Review
- Relevance of Endoplasmic Reticulum Stress Cell Signaling in Liver Cold Ischemia Reperfusion Injury.International journal of molecular sciences · 2016Review
- Intestinal injury following liver transplantation was mediated by TLR4/NF-κB activation-induced cell apoptosis.Molecular medicine reports · 2016Article
- Polyethylene Glycol Preconditioning: An Effective Strategy to Prevent Liver Ischemia Reperfusion Injury.Oxidative medicine and cellular longevity · 2016Article
- Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation.World journal of gastroenterology · 2015Article
- Effects of Institut Georges Lopez-1 and Celsior preservation solutions on liver graft injury.World journal of gastroenterology · 2015Article
- Sirtuin 1 in rat orthotopic liver transplantation: an IGL-1 preservation solution approach.World journal of gastroenterology · 2015Article
- Emerging concepts in liver graft preservation.World journal of gastroenterology · 2015Review
- Article
- Polyethylene glycol rinse solution: an effective way to prevent ischemia-reperfusion injury.World journal of gastroenterology · 2014Article
- Peroxisome proliferator-activated receptor-α activation protects against endoplasmic reticulum stress-induced HepG2 cell apoptosis.Molecular and cellular biochemistry · 2014Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Injury due to cold ischemia reperfusion (I/R) is a major cause of primary graft non-function following liver transplantation. We postulated that I/R-induced cellular damage during liver transplantation might affect the secretory pathway, particularly at the endoplasmic reticulum (ER). We examined the involvement of ER stress in organ preservation, and compared cold storage in University of Wisconsin (UW) solution and in Institute Georges Lopez-1 (IGL-1) solution. In one group of rats, livers were preserved in UW solution for 8 h at 4 °C, and then orthotopic liver transplantation was performed according to Kamada's cuff technique. In another group, livers were preserved in IGL-1 solution. The effect of each preservation solution on the induction of ER stress, hepatic injury, mitochondrial damage and cell death was evaluated. As expected, we found increased ER stress after liver transplantation. IGL-1 solution significantly attenuated ER damage by reducing the activation of three pathways of unfolded protein response and their effector molecules caspase-12, C/EBP homologous protein-10, X-box-binding protein 1, tumor necrosis factor-associated factor 2 and eukaryotic translation initiation factor 2. This attenuation of ER stress was associated with a reduction in hepatic injury and cell death. Our results show that IGL-1 solution may be a useful means to circumvent excessive ER stress reactions associated with liver transplantation, and may optimize graft quality.
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