ArticleCell death & disease2012
Synchronized ATP oscillations have a critical role in prechondrogenic condensation during chondrogenesis.
Article in Cell death & disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Electrical Stimulation of Mesenchymal Stem Cells as a Tool for Proliferation and Differentiation in Cartilage Tissue Engineering: A Scaffold-Based Approach.Bioengineering (Basel, Switzerland) · 2024Article
- Dietary restriction modulates ultradian rhythms and autocorrelation properties in mice behavior.Communications biology · 2024Article
- A Review of the Role of Bioreactors for iPSCs-Based Tissue-Engineered Articular Cartilage.Tissue engineering and regenerative medicine · 2023Review
- Coupling-dependent metabolic ultradian rhythms in confluent cells.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- RGD-Dendrimer-Poly(L-lactic) Acid Nanopatterned Substrates for the Early Chondrogenesis of Human Mesenchymal Stromal Cells Derived from Osteoarthritic and Healthy Donors.Materials (Basel, Switzerland) · 2020Article
- Control of glucose metabolism is important in tenogenic differentiation of progenitors derived from human injured tendons.PloS one · 2019Article
- Bioluminescence Assays for Monitoring Chondrogenic Differentiation and Cartilage Regeneration.Sensors (Basel, Switzerland) · 2017Review
- Electrical stimulation drives chondrogenesis of mesenchymal stem cells in the absence of exogenous growth factors.Scientific reports · 2016Article
- The importance of connexin hemichannels during chondroprogenitor cell differentiation in hydrogel versus microtissue culture models.Tissue engineering. Part A · 2015Article
- ATP promotes extracellular matrix biosynthesis of intervertebral disc cells.Cell and tissue research · 2015Article
- Dual Monitoring of Secretion and ATP Levels during Chondrogenesis Using Perfusion Culture-Combined Bioluminescence Monitoring System.BioMed research international · 2015Article
- Single-cell imaging tools for brain energy metabolism: a review.Neurophotonics · 2014Article
- Article
- Metabolic effects of TiO2 nanoparticles, a common component of sunscreens and cosmetics, on human keratinocytes.Cell death & disease · 2013Article
- Metabolomic analysis of differential changes in metabolites during ATP oscillations in chondrogenesis.BioMed research international · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The skeletal elements of embryonic limb are prefigured by prechondrogenic condensation in which secreted molecules such as adhesion molecules and extracellular matrix have crucial roles. However, how the secreted molecules are controlled to organize the condensation remains unclear. In this study, we examined metabolic regulation of secretion in prechondrogenic condensation, using bioluminescent monitoring systems. We here report on ATP oscillations in the early step of chondrogenesis. The ATP oscillations depended on both glycolysis and mitochondrial respiration, and their synchronization among cells were achieved via gap junctions. In addition, the ATP oscillations were driven by Ca(2+) oscillations and led to oscillatory secretion in chondrogenesis. Blockade of the ATP oscillations prevented cellular condensation. Furthermore, the degree of cellular condensation increased with the frequency of ATP oscillations. We conclude that ATP oscillations have a critical role in prechondrogenic condensation by inducing oscillatory secretion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.