ArticleGene therapy2013
Effect of herpes simplex virus vector-mediated interleukin-4 gene therapy on bladder overactivity and nociception.
Article in Gene therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Durable tissue-specific transgene expression in newborn mice following intraperitoneal delivery of non-cytotoxic HSV vectors.Molecular therapy. Methods & clinical development · 2025Article
- IPSE, a parasite-derived host immunomodulatory protein, is a potential therapeutic for hemorrhagic cystitis.American journal of physiology. Renal physiology · 2019Article
- IL-4 mediated by HSV vector suppresses morphine withdrawal response and decreases TNFα, NR2B, and pC/EBPβ in the periaqueductal gray in rats.Gene therapy · 2017Article
- A rat long-lasting cystitis model induced by intravesical injection of hydrogen peroxide.Physiological reports · 2017Article
- Gene therapy with HSV encoding p55TNFR gene for HIV neuropathic pain: an evidence-based mini-review.Translational perioperative and pain medicine · 2017Article
- A multiplexed analysis approach identifies new association of inflammatory proteins in patients with overactive bladder.American journal of physiology. Renal physiology · 2016Article
- Current gene therapy using viral vectors for chronic pain.Molecular pain · 2015Review
- Bladder afferent hyperexcitability in bladder pain syndrome/interstitial cystitis.International journal of urology : official journal of the Japanese Urological Association · 2014Review
- IL-4, JAK-STAT signaling, and pain.JAK-STAT · 2013Review
- IPSE, a parasite-derived, host immunomodulatory infiltrin protein, alleviates resiniferatoxin-induced bladder pain.Molecular painArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
We investigated the effects of replication-defective herpes simplex virus (HSV) vector expression of interleukin-4 (IL-4) on bladder overactivity and nociception. HSV vector expressing murine interleukin-4 (S4IL4) or the control vector expressing β-galactosidase (SHZ) were injected to the rat bladder wall. At 1 week after viral injection, in cystometry performed under urethane anesthesia, the S4IL4-treated group did not show the intercontraction intervals reduction during intravesical administration of 10 nM resiniferatoxin (RTx). At 2 weeks after viral injection, behavioral studies were performed on vector-injected animals in an awakened state. Freezing behavior induced by 3 μM RTx, administered for 1 min into the bladder, was significantly suppressed in the S4IL4 group compared with the SHZ group. Murine IL-4 levels examined by ELISA were significantly increased in bladder and bladder afferent dorsal root ganglia at 2 weeks after viral injection. The expression of IL-1β and IL-2 and bladder inflammatory responses were significantly suppressed in the RTx-irritated bladder of S4IL4-injected rats. These results indicate that HSV vector-mediated interleukin-4 expression in the bladder and bladder afferent pathways reduces the inflammatory response, bladder overactivity and nociceptive behavior induced by bladder irritation in the rat model. Therefore, IL-4 gene therapy could be a new strategy for treating urinary frequency and/or bladder pain.
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