ArticleCytokine2012
Long-term dynamic profiling of inflammatory mediators in double-hit burn and sepsis animal models.
Article in Cytokine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The trial behind it
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Who cites it
7 citing papers in PubMed.
- Endothelial progenitor cells in the host defense response.Pharmacology & therapeutics · 2023Review
- Cerium Nitrate Treatment Provides Eschar Stabilization through Reduction in Bioburden, DAMPs, and Inflammatory Cytokines in a Rat Scald Burn Model.Journal of burn care & research : official publication of the American Burn Association · 2020Article
- Endogenous Uteroglobin as Intrinsic Anti-inflammatory Signal Modulates Monocyte and Macrophage Subsets Distribution Upon Sepsis Induced Lung Injury.Frontiers in immunology · 2019Article
- Skeletal muscle atrogene expression and insulin resistance in a rat model of polytrauma.Physiological reports · 2016Article
- Dynamics of hepatic gene expression and serum cytokine profiles in single and double-hit burn and sepsis animal models.Data in brief · 2015Article
- A rat model of concurrent combined injuries (polytrauma).International journal of clinical and experimental medicine · 2015Article
- Thermal injury lowers the threshold for radiation-induced neuroinflammation and cognitive dysfunction.Radiation research · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Burn injuries together with its subsequent complications, mainly bacterial infections originating from gastrointestinal tract, activate the host immune system through stimulation of a series of local and systemic responses, including the release of inflammatory mediators. To gain a more comprehensive understanding of these complex physiological changes and to propose therapeutic approaches to combat the deleterious consequences of burn and septic shocks, it is essential to analyze animal models of burn and sepsis. In this study, we analyzed the long term profiles of cytokines and chemokines in rat models which received burn injury followed 2 days later by cecal ligation and puncture (CLP) to induce sepsis and were sacrificed at different time points within 10 days (0, 1, 2, 3, 4, 7 and 10 days). It was observed that MCP-1 concentrations were elevated in all animal models following the burn injury or CLP treatment. IP-10 concentration was persistently decreased after CLP or sham-CLP treatments. GRO/KC concentration was also increased following the burn injury and CLP. It was elucidated that, in more severe injury model which received both burn and CLP treatments, GMCSF and MIP-1α (chemokines), IL-1α (a pro-inflammatory cytokine) and IL-6 (exhibiting both pro- and anti-inflammatory behaviors) were upregulated on the 7th and 10th days, which might be to protect the host system from the subsequent complications caused by burn and sepsis. In order to elucidate critical regulatory interactions, putative transcription factors of the inflammatory mediators which have been significantly changed following the injuries were further identified by analyzing the conserved regions of the promoters of cytokines and chemokines. In conclusion, the long term profiles of the inflammatory mediators were profoundly characterized in this study to gain a comprehensive understanding of inflammatory mediators' behaviors in various injury models.
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Registered trials
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