ArticleTuberculosis (Edinburgh, Scotland)2012
Identifying multidrug resistant tuberculosis transmission hotspots using routinely collected data.
Article in Tuberculosis (Edinburgh, Scotland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Methods used in the spatial analysis of tuberculosis epidemiology: a systematic review.BMC medicine · 2018Pooled it
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- Children as sentinels of tuberculosis transmission: disease mapping of programmatic data.BMC medicine · 2020Article
- Spatiotemporal analysis of drug-resistant TB patients registered in selected districts of Karnataka, South India: a cross-sectional study.Tropical medicine and health · 2020Article
- Where is tuberculosis transmission happening? Insights from the literature, new tools to study transmission and implications for the elimination of tuberculosis.Respirology (Carlton, Vic.) · 2018Review
- The Effect of Workforce Mobility on Intervention Effectiveness Estimates.Annals of work exposures and health · 2018Article
- Article
- Spatial measurement errors in the field of spatial epidemiology.International journal of health geographics · 2016Article
- Identifying Hotspots of Multidrug-Resistant Tuberculosis Transmission Using Spatial and Molecular Genetic Data.The Journal of infectious diseases · 2016Article
- Comparing risk factors for primary multidrug-resistant tuberculosis and primary drug-susceptible tuberculosis in Jiangsu province, China: a matched-pairs case-control study.The American journal of tropical medicine and hygiene · 2015Article
- Factors associated with primary transmission of multidrug-resistant tuberculosis compared with healthy controls in Henan Province, China.Infectious diseases of poverty · 2015Article
- Geographical heterogeneity of multidrug-resistant tuberculosis in Georgia, January 2009 to June 2011.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2014Article
- Linking surveillance with action against drug-resistant tuberculosis.American journal of respiratory and critical care medicine · 2012Article
- On the spread and control of MDR-TB epidemics: an examination of trends in anti-tuberculosis drug resistance surveillance data.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapyArticle
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11 authors.
Funding
Abstract
In most countries with large drug resistant tuberculosis epidemics, only those cases that are at highest risk of having MDRTB receive a drug sensitivity test (DST) at the time of diagnosis. Because of this prioritized testing, identification of MDRTB transmission hotspots in communities where TB cases do not receive DST is challenging, as any observed aggregation of MDRTB may reflect systematic differences in how testing is distributed in communities. We introduce a new disease mapping method, which estimates this missing information through probability-weighted locations, to identify geographic areas of increased risk of MDRTB transmission. We apply this method to routinely collected data from two districts in Lima, Peru over three consecutive years. This method identifies an area in the eastern part of Lima where previously untreated cases have increased risk of MDRTB. This may indicate an area of increased transmission of drug resistant disease, a finding that may otherwise have been missed by routine analysis of programmatic data. The risk of MDR among retreatment cases is also highest in these probable transmission hotspots, though a high level of MDR among retreatment cases is present throughout the study area. Identifying potential multidrug resistant tuberculosis (MDRTB) transmission hotspots may allow for targeted investigation and deployment of resources.
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