Evidence map›Paper›PMID 22401885›Full record

ReviewTrends in cell biology2012

The ciliary transition zone: from morphology and molecules to medicine.

Peter G Czarnecki, Jagesh V Shah

Abstract readReview
In one paragraph

Review in Trends in cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 144 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Review
  6. InhaledProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. The Primary Cilia are Associated with the Axon Initial Segment in Neurons.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. The short flagella 1 (SHF1) gene inMolecular biology of the cell · 2022
    Article
  17. Review
  18. Article
  19. Article
  20. Clinical and genetic heterogeneity of primary ciliopathies (Review).International journal of molecular medicine · 2021
    Review

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Peter G CzarneckiDepartment of Systems Biology, Harvard Medical School, Boston, MA, USA.
Jagesh V Shah
Brigham and Women's Hospital · USCenter for Systems Biology · US

Funding

Polycystin channels and calciumP50DK074030 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHOU, JING · 2005 to 2009
$5.9M
NIDDK NIH HHS P50 DK074030NIDDK NIH HHS P50DK074030
6 · The paper itself

Abstract

Researchers from various disciplines, including cell and developmental biology, genetics and molecular medicine, have revealed an exceptional diversity of cellular functions that are mediated by cilia-dependent mechanisms. Recent studies have directed our attention to proteins that localize to the ciliary transition zone (TZ), a small evolutionarily conserved subcompartment that is situated between the basal body (BB) and the more distal ciliary axoneme. These reports shed light on the roles of TZ proteins in ciliogenesis, ciliary protein homeostasis and specification of ciliary signaling, and pave the way for understanding their contribution to human ciliopathies. In this review, we describe the interplay of multimeric protein complexes at the TZ, integrating morphological, genetic and proteomic data towards an account of TZ function in ciliary physiology.

Indexed as

AnimalsBiological TransportCiliaHomeostasisHumansPhenotypeSignal Transduction

Identifiers

PMID22401885
PMCPMC3331593
OpenAlexW2056061290

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.