ArticleJournal of inflammation (London, England)2012
STAT6 expression in T cells, alveolar macrophages and bronchial biopsies of normal and asthmatic subjects.
Article in Journal of inflammation (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Transcriptional Profiling in a Novel Swine Model of Traumatic Brain Injury.Neurotrauma reports · 2022Article
- Epigenetic regulation of pediatric and neonatal immune responses.Pediatric research · 2022Review
- Transfer factors peptides (Imuno TFFrontiers in immunology · 2022Article
- Article
- Anti-inflammatory potential of PI3Kδ and JAK inhibitors in asthma patients.Respiratory research · 2016Article
- Elevated H3K18 acetylation in airway epithelial cells of asthmatic subjects.Respiratory research · 2015Article
- STAT6 and lung inflammation.JAK-STAT · 2013Review
- New drugs targeting Th2 lymphocytes in asthma.Journal of occupational medicine and toxicology (London, England) · 2008Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundAsthma is characterised by increased numbers of Th2-like cells in the airways and IgE secretion. Generation of Th2 cells requires interleukin (IL)-4 and IL-13 acting through their specific receptors and activating the transcription factor, signal transducer and activator of transcription 6 (STAT6). STAT6 knockout mice fail to produce IgE, airway hyperresponsiveness and bronchoalveolar lavage eosinophilia after allergen sensitisation, suggesting a critical role for STAT6 in allergic responses.
methodsWe have investigated the expression of STAT6 in peripheral blood T-lymphocytes, alveolar macrophages and bronchial biopsies from 17 normal subjects and 18 mild-moderate steroid-naïve stable asthmatic patients.
resultsSTAT6 expression was variable and was detected in T-lymphocytes, macrophages and bronchial epithelial cells from all subjects with no difference between normal and stable asthmatic subjects.
conclusionsSTAT6 expression in different cells suggests that it may be important in regulating the expression of not only Th2-like cytokines in T cells of man, but may also regulate STAT-inducible genes in alveolar macrophages and airway epithelial cells.
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Registered trials
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