Evidence map›Paper›PMID 22401578›Full record

ArticleACS nano2012

Core/shell NaGdF4:Nd(3+)/NaGdF4 nanocrystals with efficient near-infrared to near-infrared downconversion photoluminescence for bioimaging applications.

Guanying Chen, Tymish Y Ohulchanskyy, Sha Liu, Wing-Cheung Law, Fang Wu, Mark T Swihart, Hans Agren, Paras N Prasad

Abstract read
In one paragraph

Article in ACS nano, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Intense Near-Infrared Light-Emitting NaYFMaterials (Basel, Switzerland) · 2023
    Article
  12. Synthesis Optimization of BaGdFMaterials (Basel, Switzerland) · 2022
    Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. PEI functionalized NaCeFRSC advances · 2021
    Article
  18. Review
  19. Article
  20. Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guanying ChenSchool of Chemical Engineering, Harbin Institute of Technology, 150001 Heilongjiang, People's Republic of China.
Tymish Y Ohulchanskyy
Sha Liu
Wing-Cheung Law
Fang Wu
Mark T Swihart
Hans Agren
Paras N Prasad

Funding

Novel Cancer Nanotechnology Platforms for Photodynamic Therapy and ImagingR01CA119358 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI PANDEY, RAVINDRA K. · 2005 to 2009
$3.2M
Application of Nanotechnology in Photodynamic TherapyR01CA104492 · NCI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BERGEY, EARL JAMES · 2005 to 2009
$1.3M
NCI NIH HHS R01 CA104492NCI NIH HHS R01CA104492NCI NIH HHS R01 CA119358NCI NIH HHS R01CA119358
6 · The paper itself

Abstract

We have synthesized core/shell NaGdF(4):Nd(3+)/NaGdF(4) nanocrystals with an average size of 15 nm and exceptionally high photoluminescence (PL) quantum yield. When excited at 740 nm, the nanocrystals manifest spectrally distinguished, near-infrared to near-infrared (NIR-to-NIR) downconversion PL peaked at ∼900, ∼1050, and ∼1300 nm. The absolute quantum yield of NIR-to-NIR PL reached 40% for core-shell nanoparticles dispersed in hexane. Time-resolved PL measurements revealed that this high quantum yield was achieved through suppression of nonradiative recombination originating from surface states and cross relaxations between dopants. NaGdF(4):Nd(3+)/NaGdF(4) nanocrystals, synthesized in organic media, were further converted to be water-dispersible by eliminating the capping ligand of oleic acid. NIR-to-NIR PL bioimaging was demonstrated both in vitro and in vivo through visualization of the NIR-to-NIR PL at ∼900 nm under incoherent lamp light excitation. The fact that both excitation and the PL of these nanocrystals are in the biological window of optical transparency, combined with their high quantum efficiency, spectral sharpness, and photostability, makes these nanocrystals extremely promising as optical biomaging probes.

Indexed as

Infrared RaysLuminescent MeasurementsContrast MediaFluoridesGadoliniumLigandsLightMolecular ImagingNanoparticlesNeodymiumOptical PhenomenaParticle SizeWaterContrast MediaFluoridesGadoliniumLigandsNeodymiumWater

Identifiers

PMID22401578
PMCPMC3430515

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.