ArticleJournal of women's health (2002)2012
Inflammation and cardiovascular risk in women with preterm labor.
Article in Journal of women's health (2002), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Maternal lipid profile and the relation with spontaneous preterm delivery: a systematic review.Archives of gynecology and obstetrics · 2017Pooled it
- Maternal plasma cholesterol and duration of pregnancy: A prospective cohort study in Ghana.Maternal & child nutrition · 2017Trial
- First-trimester inflammation and dyslipidemia in preterm delivery: the role of monocyte-to-HDL cholesterol ratio and lipid profiles.Irish journal of medical science · 2025Article
- Article
- Maternal Serum Cytokine Concentrations in Healthy Pregnancy and Preeclampsia.Journal of pregnancy · 2021Review
- Association of Vegetable and Animal Flesh Intake with Inflammation in Pregnant Women from India.Nutrients · 2020Article
- Vascular Function and Serum Lipids in Women with Spontaneous Preterm Delivery and Term Controls.Journal of women's health (2002) · 2019Article
- The profiles of soluble adhesion molecules in the "great obstetrical syndromes"The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2019Article
- Serum uric acid and high-risk pregnancy: an intriguing correlation in advanced pregnant women.Annals of translational medicine · 2018Article
- Metabolic endotoxaemia in childhood obesity.BMC obesity · 2015Article
- Article
- Spontaneous preterm labor and cardiovascular disease risk: one step closer to a better understanding.Journal of women's health (2002) · 2012Article
- Maternal Plasma Lipid Profile and Risk of Spontaneous Preterm Labor Study in a Sample of Iranian Women in 2019.Iranian journal of nursing and midwifery researchArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWomen with a history of preterm delivery have about twice the normal risk of cardiovascular disease (CVD). Mechanisms underlying this association are not well understood. The aim of the present study was to evaluate the relationships between selected metabolic CVD risk factors and markers of both systemic inflammation and endothelial dysfunction in women with spontaneous preterm labor (sPL).
methodsThis was a case-control study in a university tertiary referral center. Forty pregnant women with sPL were compared to 50 controls during gestation. Maternal serum triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol, glycemia, insulinemia, homeostasis model assessment (HOMA), leptin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), soluble vascular cell adhesion molecule (sVCAM), soluble intercellular adhesion molecule (sICAM), selectin, and myeloperoxidase (MPO) were measured.
resultsGestational age at study was similar in both groups (31.56±3.14 weeks of gestation vs. 31.27±2.14 weeks of gestation, p=0.62, for the control and the sPL groups, respectively). Body mass index (BMI) (21.72±2.99 vs. 23.56±3.80, p=0.01), all cholesterol fractions (HDL-C 53.44±18.22 vs. 68.32±18.38, p=0.0003; LDL-C 125.71±35.56 vs. 142.15±36.07, p=0.03, and total cholesterol 219.55±32.29 vs. 240.38±40.01, p=0.009) and MPO (3.07±0.63 vs. 3.48±0.32, p=0.0009) were significantly lower in women with sPL. Serum levels of IL-6 (0.61±0.46 vs. 0.33±0.46, p=0.007) and the ratio of total cholesterol/HDL-C (4.52±1.48 vs. 3.77±1.37, p=0.01) were significantly increased and correlated each other (r=0.21, p=0.04). Logistic regression showed that the best predictive model for sPL (R(2)=0.36, p=0.001) included BMI and total cholesterol.
conclusionsA combination of low maternal BMI, low cholesterol levels, and high total cholesterol/HDL-C ratio is present in women with sPL and is related to inflammation.
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