ReviewJournal of diabetes science and technology2012
Stress hyperglycemia in pediatric critical illness: the intensive care unit adds to the stress!
Review in Journal of diabetes science and technology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Tight glycemic control in critically ill pediatric patients: a meta-analysis and systematic review of randomized controlled trials.Pediatric research · 2018Pooled it
- Tight glycemic control in critically ill pediatric patients: a meta-analysis and systematic review of randomized controlled trials.Pediatric research · 2018Pooled it
- Development and internal validation of a clinical prediction model for septic shock in pediatric respiratory syncytial virus bronchiolitis based on routine blood biomarkers and concomitant fungal infection.Frontiers in cellular and infection microbiology · 2026Trial
- Hyperglycemia and kidney outcomes in critically ill children and young adults on continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2025Observational
- The Interaction and Implication of Stress-Induced Hyperglycemia and Cytokine Release Following Traumatic Injury: A Structured Scoping Review.Diagnostics (Basel, Switzerland) · 2024Article
- Glucose Metabolism and Stress Hyperglycemia in Critically Ill Children.Indian journal of pediatrics · 2023Review
- Response to the Letter to the Editor entitled "Glucokinase maturity-onset diabetes of the young as a mimicker of stress hyperglycemia: a case report" by Amanda Doherty-Kirby, Clin Pediatr Endocrinol 2023;32:72-75.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2023Article
- Postdischarge Glucocorticoid Use and Clinical Outcomes of Multisystem Inflammatory Syndrome in Children.JAMA network open · 2022Article
- Association between Stress Hyperglycemia and Adverse Outcomes in Children Visiting the Pediatric Emergency Department.Children (Basel, Switzerland) · 2022Article
- Prevalence and Prognostic Factors of Stress Hyperglycemia in a Pediatric Population with Acute Illness in Greece-A Prospective Observational Study.Journal of clinical medicine · 2022Article
- Providing the Best Parenteral Nutrition before and after Surgery for NEC: Macro and Micronutrients Intakes.Nutrients · 2022Review
- Nutritional Support for Pediatric Severe Traumatic Brain Injury.Frontiers in pediatrics · 2022Review
- The Effect of Various, Everyday Practices on Glucose Levels in Critically Ill Children.Journal of diabetes science and technology · 2022Article
- Stress hyperglycemia, cardiac glucotoxicity, and critically ill patient outcomes current clinical and pathophysiological evidence.Physiological reports · 2021Review
- Stress Hyperglycemia in Children and Adolescents as a Prognostic Indicator for the Development of Type 1 Diabetes Mellitus.Frontiers in pediatrics · 2021Review
- Assessment of Glycemic Control Protocol (STAR) Through Compliance Analysis Amongst Malaysian ICU Patients.Medical devices (Auckland, N.Z.) · 2020Article
- The Impact of Preoperative Fasting Duration on Blood Glucose and Hemodynamics in Children.Journal of diabetes research · 2020Article
- Outcomes Associated With Multiple Organ Dysfunction Syndrome in Critically Ill Children With Hyperglycemia.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2019Article
- Non-Diabetic Hyperglycemia in the Pediatric Age: Why, How, and When to Treat?Current diabetes reports · 2018Review
- Prevalence and outcome of stress hyperglycaemia among severely malnourished children admitted to Mulago referral and teaching hospital in Kampala, Uganda.BMC nutrition · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stress hyperglycemia (SH) commonly occurs during critical illness in children. The historical view that SH is beneficial has been questioned in light of evidence that demonstrates the association of SH with worse outcomes. In addition to intrinsic changes in glucose metabolism and development of insulin resistance, specific intensive care unit (ICU) practices may influence the development of SH during critical illness. Mechanical ventilation, vasoactive infusions, renal replacement therapies, cardiopulmonary bypass and extracorporeal life support, therapeutic hypothermia, prolonged immobility, nutrition support practices, and the use of medications are all known to mediate development of SH in critical illness. Tight glucose control (TGC) to manage SH has emerged as a promising therapy to improve outcomes in critically ill adults, but results have been inconclusive. Large variations in ICU practices across studies likely resulted in inconsistent results. Future studies of TGC need to take into account the impact of commonly used ICU practices and, ideally, standardize protocols in an attempt to improve the accuracy of conclusions from such studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.