ArticleTheranostics2012
Optical Imaging with a Cathepsin B Activated Probe for the Enhanced Detection of Esophageal Adenocarcinoma by Dual Channel Fluorescent Upper GI Endoscopy.
Article in Theranostics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- Bidirectional causal association between cathepsins and neuropsychiatric disorders: univariate and multivariate Mendelian randomization study.European archives of psychiatry and clinical neuroscience · 2026Article
- OBSERVE: guidelines for the refinement of rodent cancer models.Nature protocols · 2024Review
- Development of a Peptide-Based Nano-Sized Cathepsin B Inhibitor for Anticancer Therapy.Pharmaceutics · 2023Article
- A Cathepsin-Targeted Quenched Activity-Based Probe Facilitates Enhanced Detection of Human Tumors during Resection.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022Article
- Preclinical Evaluation of an Activity-Based Probe for Intraoperative Imaging of Esophageal Cancer.Molecular imaging · 2022Article
- Molecular probes for selective detection of cysteine cathepsins.Organic & biomolecular chemistry · 2021Review
- pH-dependent and cathepsin B activable CaCOInternational journal of nanomedicine · 2019Article
- Evaluation of optical imaging agents in a fluorescence-guided surgical model of head and neck cancer.Surgical oncology · 2018Article
- Improved xenograft efficiency of esophageal adenocarcinoma cell lines through in vivo selection.Oncology reports · 2017Article
- Cathepsins in digestive cancers.Oncotarget · 2017Review
- Review
- Enzymatically activated near infrared nanoprobes based on amphiphilic block copolymers for optical detection of cancer.Lasers in surgery and medicine · 2015Article
- Comparison of multiple enzyme activatable near-infrared fluorescent molecular probes for detection and quantification of inflammation in murine colitis models.Inflammatory bowel diseases · 2014Article
- Detection of esophageal squamous cell carcinoma by cathepsin B activity in nude mice.PloS one · 2014Article
- In vivo imaging of tissue-remodeling activity involving infiltration of macrophages by a systemically administered protease-activatable probe in colon cancer tissues.Translational oncology · 2013Article
- Molecular imaging in gastroenterology.Nature reviews. Gastroenterology & hepatology · 2013Review
- Endoscopic molecular imaging of cancer.Future oncology (London, England) · 2013Review
- Noninvasive monitoring of pulmonary fibrosis by targeting matrix metalloproteinases (MMPs).Molecular pharmaceutics · 2013Article
- Nanotheranostics for personalized medicine.Expert review of molecular diagnostics · 2013Review
- Optical imaging of periostin enables early endoscopic detection and characterization of esophageal cancer in mice.Gastroenterology · 2013Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite significant advances in diagnosis and treatment, the prognosis of esophageal adenocarcinoma remains poor highlighting the importance of early detection. Although white light (WL) upper endoscopy can be used for screening of the esophagus, it has limited sensitivity for early stage disease. Thus, development of new imaging technology to improve the diagnostic capabilities of upper GI endoscopy for early detection of esophageal adenocarcinoma is an important unmet need. The goal of this study was to develop a method for the detection of malignant lesions in the esophagus using WL upper endoscopy combined with near infrared (NIR) imaging with a protease activatable probe (Prosense750) selective for cathepsin B (CTSB). An orthotopic murine model for distal esophageal adenocarcinoma was generated through the implantation of OE-33 and OE-19 human esophageal adenocarcinoma lines in immunocompromised mice. The mice were imaged simultaneously for WL and NIR signal using a custom-built dual channel upper GI endoscope. The presence of tumor was confirmed by histology and target to background ratios (TBR) were compared for both WL and NIR imaging. NIR imaging with ProSense750 significantly improved upon the TBRs of esophageal tumor foci, with a TBR of 3.64±0.14 and 4.50±0.11 for the OE-33 and OE-19 tumors respectively, compared to 0.88±0.04 and 0.81±0.02 TBR for WL imaging. The combination of protease probes with novel imaging devices has the potential to improve esophageal tumor detection by fluorescently highlighting neoplastic regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.