ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Gap-junctional coupling of mammalian rod photoreceptors and its effect on visual detection.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Rod/Cone Gap Junctions: Plastic Electrical Synapses at the First Visual Synapse.Annual review of vision science · 2026Review
- Retinal Cx36 gap junctions in the inner and outer plexiform layers differentially control visual thresholds.iScience · 2026Article
- When microscopy and electrophysiology meet connectomics-Steve Massey's contribution to unraveling the structure and function of the rod/cone gap junction.Frontiers in ophthalmology · 2023Review
- Analysis of rod/cone gap junctions from the reconstruction of mouse photoreceptor terminals.eLife · 2022Article
- Article
- Interphotoreceptor coupling: an evolutionary perspective.Pflugers Archiv : European journal of physiology · 2021Review
- Development and maintenance of vision's first synapse.Developmental biology · 2021Review
- Differential Contribution of Gap Junctions to the Membrane Properties of ON- and OFF-Bipolar Cells of the Rat Retina.Cellular and molecular neurobiology · 2021Article
- Rhodopsin-mediated light-off-induced protein kinase A activation in mouse rod photoreceptor cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Molecular and functional architecture of the mouse photoreceptor network.Science advances · 2020Article
- Dopaminergic Modulation of Signal Processing in a Subset of Retinal Bipolar Cells.Frontiers in cellular neuroscience · 2020Article
- Paired Recording to Study Electrical Coupling Between Photoreceptors in Mouse Retina.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Temporal resolution of single-photon responses in primate rod photoreceptors and limits imposed by cellular noise.Journal of neurophysiology · 2019Article
- Connexin 36 and rod bipolar cell independent rod pathways drive retinal ganglion cells and optokinetic reflexes.Vision research · 2016Article
- Expression and Localization of Connexins in the Outer Retina of the Mouse.Journal of molecular neuroscience : MN · 2016Article
- Direct Evidence for Daily Plasticity of Electrical Coupling between Rod Photoreceptors in the Mammalian Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Rod electrical coupling is controlled by a circadian clock and dopamine in mouse retina.The Journal of physiology · 2015Article
- Rods in daylight act as relay cells for cone-driven horizontal cell-mediated surround inhibition.Nature neuroscience · 2014Article
- Sparsity and compressed coding in sensory systems.PLoS computational biology · 2014Article
- The synaptic and circuit mechanisms underlying a change in spatial encoding in the retina.Neuron · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The presence of gap junctions between rods in mammalian retina suggests a role for rod-rod coupling in human vision. Rod coupling is known to reduce response variability, but because junctional conductances are not known, the downstream effects on visual performance are uncertain. Here we assessed rod coupling in guinea pig retina by measuring: (1) the variability in responses to dim flashes, (2) Neurobiotin tracer coupling, and (3) junctional conductances. Results were consolidated into an electrical network model and a model of human psychophysical detection. Guinea pig rods form tracer pools of 1 to ∼20 rods, with junctional conductances averaging ∼350 pS. We calculate that coupling will reduce human dark-adapted sensitivity ∼10% by impairing the noise filtering of the synapse between rods and rod bipolar cells. However, coupling also mitigates synaptic saturation and is thus calculated to improve sensitivity when stimuli are spatially restricted or are superimposed over background illumination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.