ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Neurofibromin modulates adult hippocampal neurogenesis and behavioral effects of antidepressants.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Pediatric Patient With Neurofibromatosis I Presenting With Perceptual Disturbances and a Suicide Attempt.Cureus · 2024Article
- Review
- Assessing Psychiatric Comorbidity and Pharmacologic Treatment Patterns Among Patients With Neurofibromatosis Type 1.Cureus · 2021Article
- Early stem cell aging in the mature brain.Cell stem cell · 2021Article
- The impact of RASopathy-associated mutations on CNS development in mice and humans.Molecular brain · 2019Review
- The Noonan Syndrome-linked Raf1L613V mutation drives increased glial number in the mouse cortex and enhanced learning.PLoS genetics · 2019Article
- Neogenin, a regulator of adult hippocampal neurogenesis, prevents depressive-like behavior.Cell death & disease · 2018Article
- TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response.Nature communications · 2017Article
- An L-Glutamine Transporter Isoform for Neurogenesis Facilitated by L-Theanine.Neurochemical research · 2017Review
- Brain Tumor Stem Cells Remain in Play.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2017Review
- Neurofibromin Regulates Seizure Attacks in the Rat Pilocarpine-Induced Model of Epilepsy.Molecular neurobiology · 2016Article
- Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation.Nature neuroscience · 2015Article
- Layer 2/3 pyramidal cells in the medial prefrontal cortex moderate stress induced depressive behaviors.eLife · 2015Article
- Increasing Adult Hippocampal Neurogenesis is Sufficient to Reduce Anxiety and Depression-Like Behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Cells of origin in the embryonic nerve roots for NF1-associated plexiform neurofibroma.Cancer cell · 2014Article
- NF1 regulation of RAS/ERK signaling is required for appropriate granule neuron progenitor expansion and migration in cerebellar development.Genes & development · 2014Article
- Hippocampal granule cell pathology in epilepsy - a possible structural basis for comorbidities of epilepsy?Epilepsy & behavior : E&B · 2014Review
- The Learning Disabilities Network (LeaDNet): using neurofibromatosis type 1 (NF1) as a paradigm for translational research.American journal of medical genetics. Part A · 2012Review
- The molecular basis of cognitive deficits in pervasive developmental disorders.Learning & memory (Cold Spring Harbor, N.Y.) · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Neurogenesis persists in the rodent dentate gyrus (DG) throughout adulthood but declines with age and stress. Neural progenitor cells (NPCs) residing in the subgranular zone of the DG are regulated by an array of growth factors and respond to the microenvironment, adjusting their proliferation level to determine the rate of neurogenesis. Here we report that genetic deletion of neurofibromin (Nf1), a tumor suppressor with RAS-GAP activity, in adult NPCs enhanced DG proliferation and increased generation of new neurons in mice. Nf1 loss-associated neurogenesis had the functional effect of enhancing behavioral responses to subchronic antidepressants and, over time, led to spontaneous antidepressive-like behaviors. Thus, our findings establish an important role for the Nf1-Ras pathway in regulating adult hippocampal neurogenesis, and demonstrate that activation of adult NPCs is sufficient to modulate depression- and anxiety-like behaviors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.