ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Mechanisms of taste bud cell loss after head and neck irradiation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 93 citations in OpenAlex.
- Converging Signaling Networks Drive Taste Bud Morphogenesis, Turnover, and Regeneration.International journal of molecular sciences · 2026Review
- Ribosomal Profiling of the Geniculate Ganglion Identifies the Receptor ALK as Critical for the Development and Maintenance of Oral Sensory Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Obesity-induced taste bud loss in mice is only partially remediated long after return to a healthy weight.International journal of obesity (2005) · 2026Article
- Taste disorders in cancer patients and current therapeutic approaches: a narrative review of an understudied topic in supportive care.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Review
- FlavorCharter: Development of a Smartphone App for Quantifying Food Flavor.Proceedings ... ICDM workshops. IEEE International Conference on Data Mining · 2025Article
- Developing and regenerating a sense of taste.Current topics in developmental biology · 2025Review
- Therapy-Associated Saliva and Taste change Evaluation (TASTE) in head & neck cancer patients undergoing radiotherapy: a study protocol.BMC cancer · 2024Observational
- Cyclophosphamide induces the loss of taste bud innervation in mice.Chemical senses · 2024Article
- Physiology of the tongue with emphasis on taste transduction.Physiological reviews · 2023Review
- Cisplatin attenuates taste cell homeostasis and induces inflammatory activation in the circumvallate papilla.Theranostics · 2023Article
- Dose-Response Relationship between Head and Neck Radiation and Damages to Gustatory Cells in Mice.Journal of oncology · 2023Article
- Radioprotective potential of whey protein against gamma irradiation-induced lingual damage.Frontiers in pharmacology · 2023Article
- Oral Health Management and Rehabilitation for Patients with Oral Cancer: A Narrative Review.Healthcare (Basel, Switzerland) · 2022Review
- METTL3-mediated mInternational journal of oral science · 2022Article
- The influence of radiation dose on taste impairment in a prospective observational study cohort of oropharyngeal cancer patients.Acta oncologica (Stockholm, Sweden) · 2022Observational
- Effects of dose-dependent response to gamma radiation on circumvallate papilla by expression of caspase-3 in vivo.The Saudi dental journal · 2021Article
- Molecular and Neural Mechanism of Dysphagia Due to Cancer.International journal of molecular sciences · 2021Review
- Generation and Culture of Lingual Organoids Derived from Adult Mouse Taste Stem Cells.Journal of visualized experiments : JoVE · 2021Article
- Development and validation of a contouring guideline for the taste bud bearing tongue mucosa.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2021Article
- Isolated taste disorders in patients referred to a flavor clinic with taste and smell loss.Brain and behavior · 2021Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Taste loss in human patients following radiotherapy for head and neck cancer is a common and significant problem, but the cellular mechanisms underlying this loss are not understood. Taste stimuli are transduced by receptor cells within taste buds, and like epidermal cells, taste cells are regularly replaced throughout adult life. This renewal relies on progenitor cells adjacent to taste buds, which continually supply new cells to each bud. Here we treated adult mice with a single 8 Gy dose of x-ray irradiation to the head and neck, and analyzed taste epithelium at 1-21 d postirradiation (dpi). We found irradiation targets the taste progenitor cells, which undergo cell cycle arrest (1-3 dpi) and apoptosis (within 1 dpi). Taste progenitors resume proliferation at 5-7 dpi, with the proportion of cells in S and M phase exceeding control levels at 5-6 and 6 dpi, respectively, suggesting that proliferation is accelerated and/or synchronized following radiation damage. Using 5-bromo-2-deoxyuridine birthdating to identify newborn cells, we found that the decreased proliferation following irradiation reduces the influx of cells at 1-2 dpi, while the robust proliferation detected at 6 dpi accelerates entry of new cells into taste buds. In contrast, the number of differentiated taste cells was not significantly reduced until 7 dpi. These data suggest a model where continued natural taste cell death, paired with temporary interruption of cell replacement, underlies taste loss after irradiation.
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