ArticleDiabetes care2012
Vitamin D levels predict all-cause and cardiovascular disease mortality in subjects with the metabolic syndrome: the Ludwigshafen Risk and Cardiovascular Health (LURIC) Study.
Article in Diabetes care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association Between the Circulating Level of 25-Hydroxyvitamin D and Clinical Results After Cardiac Surgery: A Meta-Analysis and Systematic Review.Frontiers in cardiovascular medicine · 2021Pooled it
- Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D.American journal of public health · 2014Pooled it
- Chewing betel quid and the risk of metabolic disease, cardiovascular disease, and all-cause mortality: a meta-analysis.PloS one · 2013Pooled it
- Vitamin A and D Absorption in Adults with Metabolic Syndrome versus Healthy Controls: A Pilot Study Utilizing Targeted and Untargeted LC-MS Lipidomics.Molecular nutrition & food research · 2021Trial
- Effect of paricalcitol on left ventricular mass and function in CKD--the OPERA trial.Journal of the American Society of Nephrology : JASN · 2014Trial
- Association between serum 25(OH)D, oxidative balance score, and mortality among individuals with metabolic syndrome: a cohort study.Diabetology & metabolic syndrome · 2025Article
- Physiology of Vitamin D-Focusing on Disease Prevention.Nutrients · 2024Review
- Association of serum 25-hydroxyvitamin D with the incidence of 16 cancers, cancer mortality, and all-cause mortality among individuals with metabolic syndrome: a prospective cohort study.European journal of nutrition · 2023Article
- Clusters of prediabetes and type 2 diabetes stratify all-cause mortality in a cohort of participants undergoing invasive coronary diagnostics.Cardiovascular diabetology · 2023Article
- The Role of Vitamin D for Human Health: The Challenge of the Right Study Designs and Interpretation.Nutrients · 2023Article
- Is Hypovitaminosis D a Risk Factor for Heart Failure?Life (Basel, Switzerland) · 2023Review
- Article
- Hypovitaminosis D and Metabolic Syndrome in Postmenopausal Women.Healthcare (Basel, Switzerland) · 2022Review
- Article
- The Role of Vitamin DJournal of clinical medicine · 2022Article
- Serum levels of vitamin D and tumour necrosis factor-alpha in adults with metabolic syndrome.European journal of clinical and experimental medicine · 2021Article
- Cutoff point estimation for serum vitamin D concentrations to predict cardiometabolic risk in Brazilian children.European journal of clinical nutrition · 2020Article
- Vitamin D deficiency and co-morbidities in COVID-19 patients - A fatal relationship?NFS journal · 2020Article
- A Review of Vitamin D in Spinal Surgery: Deficiency Screening, Treatment, and Outcomes.International journal of spine surgery · 2020Article
- Intronic Variants in OCT1 are Associated with All-Cause and Cardiovascular Mortality in Metformin Users with Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectiveOptimal vitamin D levels are associated with reduced cardiovascular and all-cause mortality. We investigated whether optimal 25-hydroxyvitamin D (25[OH]D) is protective in individuals with the metabolic syndrome. RESEARCH DESIGN AND
methodsThe Ludwigshafen Risk and Cardiovascular Health (LURIC) study is a cohort study of subjects referred for coronary angiography between 1997 and 2000, from which 1,801 with the metabolic syndrome were investigated. Mortality was tracked for a median of 7.7 years. Multivariable survival analysis was used to estimate the association between 25(OH)D levels and mortality.
resultsMost subjects (92%) had suboptimal levels of 25(OH)D (<75 nmol/L), with 22.2% being severely deficient (<25 nmol/L). During follow-up, 462 deaths were recorded, 267 (57.8%) of which were cardiovascular in origin. After full adjustment, including the metabolic syndrome components, those with optimal 25(OH)D levels showed a substantial reduction in all-cause (hazard ratio [HR] 0.25 [95% CI 0.13-0.46]) and cardiovascular disease mortality (0.33 [0.16-0.66]) compared with those with severe vitamin D deficiency. For specific cardiovascular disease mortality, there was a strong reduction for sudden death (0.15 [0.04-0.63]) and congestive heart failure (0.24 [0.06-1.04]), but not for myocardial infarction. The reduction in mortality was dose-dependent for each of these causes.
conclusionsOptimal 25(OH)D levels substantially lowered all-cause and cardiovascular disease mortality in subjects with the metabolic syndrome. These observations call for interventional studies that test whether vitamin D supplementation provides a useful adjunct in reducing mortality in these subjects.
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