ReviewAdvances in experimental medicine and biology2012
The molecular basis of mechanosensory transduction.
Review in Advances in experimental medicine and biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Magnetic nanoparticle formulations to activate TREK and Piezo mechanosensitive ion channels (MICA) for enhanced osteogenesis.Regenerative biomaterials · 2026Article
- Polyphenols and exercise in autophagy regulation: potential benefits for cancer management and healthspan.Frontiers in nutrition · 2025Review
- Mechanotransduction in hippocampal neurons operates under localized low picoNewton forces.iScience · 2022Article
- How do you feel? A warm and touching 2021 Nobel tribute.The Journal of clinical investigation · 2021Article
- A small molecule screen identifies novel inhibitors of mechanosensory nematocyst discharge in Hydra.Scientific reports · 2021Article
- Transient receptor potential canonical 1 channel mediates the mechanical stress‑induced epithelial‑mesenchymal transition of human bronchial epithelial (16HBE) cells.International journal of molecular medicine · 2020Article
- The Mechanical Microenvironment in Breast Cancer.Cancers · 2020Review
- Editorial: Mechanobiology: Emerging Tools and Methods.Frontiers in bioengineering and biotechnology · 2020Article
- Neurodynamic analysis of Merkel cell-neurite complex transduction mechanism during tactile sensing.Cognitive neurodynamics · 2019Article
- A TR(i)P to Cell Migration: New Roles of TRP Channels in Mechanotransduction and Cancer.Frontiers in physiology · 2019Review
- The Functional Response of Mesenchymal Stem Cells to Electron-Beam Patterned Elastomeric Surfaces Presenting Micrometer to Nanoscale Heterogeneous Rigidity.Advanced materials (Deerfield Beach, Fla.) · 2017Article
- Neuronal cytoskeletal gene dysregulation and mechanical hypersensitivity in a rat model of Rett syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- From Biological Cilia to Artificial Flow Sensors: Biomimetic Soft Polymer Nanosensors with High Sensing Performance.Scientific reports · 2016Article
- Morphological restriction of human coronary artery endothelial cells substantially impacts global gene expression patterns.The FEBS journal · 2013Article
- Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Characterization of Optimal Strain, Frequency and Duration of Mechanical Loading on Skeletal Myotubes' Biological Responses.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Multiple senses, including hearing, touch and osmotic regulation, require the ability to convert force into an electrical signal: A process called mechanotransduction. Mechanotransduction occurs through specialized proteins that open an ion channel pore in response to a mechanical stimulus. Many of these proteins remain unidentified in vertebrates, but known mechanotransduction channels in lower organisms provide clues into their identity and mechanism. Bacteria, fruit flies and nematodes have all been used to elucidate the molecules necessary for force transduction. This chapter discusses many different mechanical senses and takes an evolutionary approach to review the proteins responsible for mechanotransduction in various biological kingdoms.
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Registered trials
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