ArticlePharmaceutical research2012
Human pancreatic polypeptide in a phospholipid-based micellar formulation.
Article in Pharmaceutical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
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- Engineered tools to study endocrine dysfunction of pancreas.Biophysics reviews · 2024Review
- BH3-mimetics: recent developments in cancer therapy.Journal of experimental & clinical cancer research : CR · 2021Review
- Cytotoxic, Apoptotic and Genotoxic Effects of Lipid-Based and Polymeric Nano Micelles, an In Vitro Evaluation.Toxics · 2017Article
- When Is It Important to Measure Unbound Drug in Evaluating Nanomedicine Pharmacokinetics?Drug metabolism and disposition: the biological fate of chemicals · 2016Review
- A new lipid-based nano formulation of vinorelbine.AAPS PharmSciTech · 2014Article
- Recent developments in protein and peptide parenteral delivery approaches.Therapeutic delivery · 2014Article
- The future role of gut hormones in the treatment of obesity.Therapeutic advances in chronic disease · 2014Review
- Solubilization of therapeutic agents in micellar nanomedicines.Langmuir : the ACS journal of surfaces and colloids · 2013Article
- A novel peptide nanomedicine for treatment of pancreatogenic diabetes.Nanomedicine : nanotechnology, biology, and medicine · 2013Article
- Novel, biocompatible, and disease modifying VIP nanomedicine for rheumatoid arthritis.Molecular pharmaceutics · 2013Article
- Biomarkers of Alzheimer's disease among Mexican Americans.Journal of Alzheimer's disease : JAD · 2013Article
- Improvement of in vivo efficacy of recombinant human erythropoietin by encapsulation in PEG-PLA micelle.International journal of nanomedicine · 2013Article
- VIP-targeted Cytotoxic Nanomedicine for Breast Cancer.Drug delivery and translational research · 2012Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purposePancreatic polypeptide (PP) has important glucoregulatory functions and thereby holds significance in the treatment of diabetes and obesity. However, short plasma half-life and aggregation propensity of PP in aqueous solution, limits its therapeutic application. To address these issues, we prepared and characterized a formulation of PP in sterically stabilized micelles (SSM) that protects and stabilizes PP in its active conformation.
methodsPP-SSM was prepared by incubating PP with SSM dispersion in buffer. Peptide-micelle association and freeze-drying efficacy of the formulation was characterized in phosphate buffers with or without sodium chloride using dynamic light scattering, fluorescence spectroscopy and circular dichroism. The degradation kinetics of PP-SSM in presence of proteolytic enzyme was determined using HPLC and bioactivity of the formulation was evaluated by in vitro cAMP inhibition study.
resultsPP self-associated with SSM and this interaction was influenced by presence/absence of sodium chloride in the buffer. The formulation was effectively lyophilized, demonstrating feasibility for its long-term storage. The stability of peptide against proteolytic degradation was significantly improved and PP in SSM retained its bioactivity in vitro.
conclusionsSelf-association of PP with phospholipid micelles addressed the delivery issues of the peptide. This nanomedicine should be further developed for the treatment of diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.