Trial reportJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2012
Transient ischemic dilation for coronary artery disease in quantitative analysis of same-day sestamibi myocardial perfusion SPECT.
Trial report in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Machine Learning-Based Automated Diagnostic Systems Developed for Heart Failure Prediction Using Different Types of Data Modalities: A Systematic Review and Future Directions.Computational and mathematical methods in medicine · 2022Pooled it
- Diagnostic and prognostic significance of transient ischemic dilation (TID) in myocardial perfusion imaging: A systematic review and meta-analysis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Pooled it
- Transient ischemic dilation withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2026Trial
- Prognostic significance of non-perfusion parameters of cadmium-zinc-telluride single-photon emission computed tomography myocardial perfusion imaging for individuals with normal myocardial perfusion: a large-scale single-center retrospective cohort study.Annals of nuclear medicine · 2025Article
- Relationship between left ventricular cavity size and transient ischaemic dilation ratio on dipyridamole stress single-photon emission computerized tomography myocardial perfusion imaging in a female Asian population.European heart journal. Imaging methods and practice · 2025Article
- Quality metrics for single-photon emission computed tomography myocardial perfusion imaging: an ASNC information statement.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Review
- Relationship between Semi-Quantitative Parameters of Thallium-201 Myocardial Perfusion Imaging and Coronary Artery Disease.Diagnostics (Basel, Switzerland) · 2020Article
- Non ECG gated supine to prone left ventricular volume ratio: a novel marker for myocardial ischemia.The international journal of cardiovascular imaging · 2020Article
- Quantitative Clinical Nuclear Cardiology, Part 1: Established Applications.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Review
- Quantitative Clinical Nuclear Cardiology, Part 1: Established Applications.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019Review
- How variable are the volumetric measurements from gated perfusion SPECT when a one-day stress-rest protocol is used?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Do we really need to look at volumetric measurements withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging Guidelines: Instrumentation, Acquisition, Processing, and Interpretation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Review
- Prognostic Value of Combined Clinical and Myocardial Perfusion Imaging Data Using Machine Learning.JACC. Cardiovascular imaging · 2018Article
- Transient ischemic dilation: An old but not obsolete marker of extensive coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Deciding wisely: A case for an effective use of myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Normal limits for transient ischemic dilation withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Computer derived transient ischemic dilation ratio for identifying extensive coronary artery disease using a CZT camera and imaging in the upright position.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Impact of imaging protocol on left ventricular ejection fraction using gated-SPECT myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- SPECT and PET in ischemic heart failure.Heart failure reviews · 2017Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundTransient ischemic dilation (TID) of the left ventricle in myocardial perfusion SPECT (MPS) has been shown to be a clinically useful marker of severe coronary artery disease (CAD). However, TID has not been evaluated for 99mTc-sestamibi rest/stress protocols (Mibi-Mibi). We aimed to develop normal limits and evaluate diagnostic power of TID ratio for Mibi-Mibi scans.
methodsTID ratios were automatically derived from static rest/stress MPS (TID) and gated rest/stress MPS from the end-diastolic phase (TID(ed)) in 547 patients who underwent Mibi-Mibi scans [215 patients with correlating coronary angiography and 332 patients with low likelihood (LLk) of CAD]. Scans were classified as severe (≥ 70% stenosis in proximal left anterior descending (pLAD) artery or left main (LM), or ≥ 90% in ≥ 2 vessels), mild to moderate (≥ 90% stenosis in 1 vessel or ≥ 70%-90% in ≥ 1 vessel except pLAD or LM), and normal (<70% stenosis or LLk group). Another classification based on the angiographic Duke prognostic CAD index (DI) was also applied: DI ≥ 50, 30 ≤ DI < 50 and DI < 30 or LLk group.
resultsThe upper normal limits were 1.19 for TID and 1.23 for TID(ed) as established in 259 LLk patients. Both ratios increased with disease severity (P < .0001). Incidence of abnormal TID increased from 2% in normal patients to >36% in patients with severe CAD. Similarly, when DI was used to classify disease severity, the average ratios showed significant increasing trend with DI increase (P < .003); incidence of abnormal TID also increased with increasing DI. The incidence of abnormal TID in the group with high perfusion scores significantly increased compared to the group with low perfusion scores (stress total perfusion deficit, TPD < 3%) (P < .0001). The sensitivity for detecting severe CAD improved for TID when added to mild to moderate perfusion abnormality (3% ≤ TPD < 10%): 71% vs 64%, P < .05; and trended to improve for TID(ed)/TID(es): 69% vs 64%, P = .08, while the accuracy remained consistent if abnormal TID was considered as a marker in addition to stress TPD. Similar results were obtained when DI was used for the definition of severe CAD (sensitivity: 76% vs 66%, P < .05 when TID was combined with stress TPD).
conclusionTID ratios obtained from gated or ungated Mibi-Mibi MPS and are useful markers of severe CAD.
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