Evidence map›Paper›PMID 22399312›Full record

ArticleMolecular biology reports2012

Polymorphisms of the pro-opiomelanocortin and agouti-related protein genes and their association with chicken production traits.

Yichun Bai, Guirong Sun, Xiangtao Kang, Ruili Han, Yadong Tian, Hong Li, Yang Wei, Shikang Zhu

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Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yichun BaiCollege of Livestock Husbandry and Veterinary Engineering, Henan Research Center of Breeding Resources for Poultry, Henan Agricultural University, No.95 Wenhua Road, Zhengzhou, Henan 450002, People's Republic of China. yichun1979@126.com
Guirong Sun
Xiangtao Kang
Ruili Han
Yadong Tian
Hong Li
Yang Wei
Shikang Zhu
Henan Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pro-opiomelanocortin (POMC) and agouti-related protein (AGRP) are hypothalamic neuropeptides that play a central role in the regulation of food intake and energy expenditure and for this reason the variations in the POMC and AGRP genes in chicken were examined by screening the DNA pools. Two silent cSNPs mutations in POMC gene and one silent cSNP mutation in AGRP gene were identified. PCR-restriction fragment length polymorphism (RFLP) was used to test the cSNPs c. C495T in the POMC and c. C9T in the AGRP gene in the F2 resource population of Gushi chicken crossed with Anak broiler. The association analysis on the polymorphisms of POMC, AGRP gene and production traits showed that the c. C495T mutation in the POMC gene was significantly linked to the pelvis breadth at 4 weeks of age (P = 0.035), body weight at 2 weeks of age (P = 0.013) and was highly significantly linked to the chest depth at 12 weeks of age (P = 0.006). The c. T9T genotype in the AGRP gene was associated with a low breast muscle water loss rate (P = 0.025), increased chest width at 12 weeks of age (P = 0.005) and body weight at 2 weeks of age (P = 0.036), a high slaughter rate (P = 0.049) and semi-evisceration weight (P = 0.019). These findings may have important implications for the molecular aspects of chicken breeding.

Indexed as

Agouti-Related ProteinAnimalsBase SequenceBody SizeBody WeightBreedingChickensFemaleGenetic VariationMaleMeatPolymorphism, Single NucleotidePro-OpiomelanocortinSequence Analysis, DNAAgouti-Related ProteinPro-Opiomelanocortin

Identifiers

PMID22399312
OpenAlexW2020119412

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.