ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2012
Body mass index and survival in esophageal adenocarcinoma treated with chemoradiotherapy followed by esophagectomy.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Prediagnostic adult body mass index change and esophageal adenocarcinoma survival.Cancer medicine · 2020Article
- Visceral Adipose Tissue Modulates Radiosensitivity in Oesophageal Adenocarcinoma.International journal of medical sciences · 2019Article
- Anastomotic leak and neoadjuvant chemoradiotherapy in esophageal cancer.Journal of gastrointestinal oncology · 2018Article
- Adjuvant chemotherapy and outcomes in esophageal carcinoma.Journal of gastrointestinal oncology · 2017Article
- CT-based assessment of visceral adiposity and outcomes for esophageal adenocarcinoma.Journal of gastrointestinal oncology · 2017Article
- The fat and the bad: Mature adipocytes, key actors in tumor progression and resistance.Oncotarget · 2017Review
- The role of obesity in oesophageal cancer development.Therapeutic advances in gastroenterology · 2014Review
- Clinical management of obese patients with cancer.Nature reviews. Clinical oncology · 2013Review
- Comparison of the prognostic values of various nutritional parameters in patients with esophageal squamous cell carcinoma from Southern China.Journal of thoracic disease · 2013Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBody mass index (BMI) has been linked with inferior outcomes in gastrointestinal malignancies. The purpose of this study is to evaluate the effect of BMI on survival in patients with esophageal adenocarcinoma.
methodsMedical records were analyzed for patients who underwent esophagectomy after neoadjuvant chemoradiotherapy (nCRT) for adenocarcinoma from 2000 to the present. Patients were grouped into BMI ≤ 25, >25-30, >30-35, and BMI >35. Overall survival (OS) and disease-free survival (DFS) were analyzed using the Kaplan-Meier method. Multivariate analysis (MVA) was performed using Cox proportional hazard regression model.
resultsWe identified 303 patients for the analysis. The only difference in patient characteristics between groups was gender. We found no difference in OS and DFS associated with BMI (p=0.3297 for OS; p=0.5950 for DFS). There were no differences in postoperative complications or mortality between BMI groups. MVA revealed that higher stage and less than a complete response to nCRT were prognostic for worse OS and DFS, while age, gender, type of surgery, year of diagnosis, and BMI were not prognostic.
conclusionsBMI was neither associated with surgical complications nor survival in patients with esophageal adenocarcinoma treated with nCRT. BMI should not be considered a contraindication to surgical resection after nCRT.
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