ArticleBrain and behavior2011
Genetically determined dopamine availability predicts disposition for depression.
Article in Brain and behavior, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Genetic Variants Associated With Resilience in Human and Animal Studies.Frontiers in psychiatry · 2022Pooled it
- Decreased dopamine brain reactivity in marijuana abusers is associated with negative emotionality and addiction severity.Proceedings of the National Academy of Sciences of the United States of America · 2014Trial
- Molecular genetic basis of the primary emotions in young adults: an exploratory analysis of genetic polymorphisms across dopamine, serotonin, oxytocin, endogenous opioid, and neurotrophic factor pathways.Frontiers in pharmacology · 2025Article
- The Structural Basis of the Activity Cliff in Modafinil-Based Dopamine Transporter Inhibitors.Biomolecules · 2024Article
- TheBiomedicines · 2023Review
- Disordered eating in early childhood: DRD4 and DAT1 gene polymorphisms and quality of mother-child interaction.Eating and weight disorders : EWD · 2022Article
- Attenuated dopamine signaling after aversive learning is restored by ketamine to rescue escape actions.eLife · 2021Article
- The Mesolimbic Dopamine System in Chronic Pain and Associated Affective Comorbidities.Biological psychiatry · 2020Review
- Predictors of recurrence of major depressive disorder.PloS one · 2020Article
- Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder.Frontiers in psychiatry · 2020Review
- Systems pharmacogenomics - gene, disease, drug and placebo interactions: a case study in COMT.Pharmacogenomics · 2019Article
- The Catechol-O-Methyltransferase and Dopamine Transporter Genes Moderated the Impact of Peer Relationships on Adolescent Depressive Symptoms: A Gene-Gene-Environment Study.Journal of youth and adolescence · 2018Article
- Antidepressant treatment effects on dopamine transporter availability in patients with major depression: a prospectiveJournal of neural transmission (Vienna, Austria : 1996) · 2018Article
- Affective Neuroscience Theory and Personality: An Update.Personality neuroscience · 2018Article
- Article
- The Isomeric Preference of an Atypical Dopamine Transporter Inhibitor Contributes to Its Selection of the Transporter Conformation.ACS chemical neuroscience · 2017Article
- Identifying affective personality profiles: A latent profile analysis of the Affective Neuroscience Personality Scales.Scientific reports · 2017Article
- The effects of DAT1 genotype on fMRI activation in an emotional go/no-go task.Brain imaging and behavior · 2017Article
- Primary Emotional Systems and Personality: An Evolutionary Perspective.Frontiers in psychology · 2017Article
- Association betweenNeuropsychiatric disease and treatment · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although prominent personality theories postulate orthogonality between traits of positive emotionality (PEM) and negative emotionality (NEM), empirical evidence often demonstrates the opposite indicating a negative relationship. Therefore, it is not surprising that dopaminergic (DA) gene loci have been related to traits of positive and of NEM. The present genetic association study investigates the influence of two functional DA gene polymorphisms on Sadness as defined by the Affective Neuroscience Personality Scales (ANPS) in healthy Caucasians (n = 1041). We observed a significant interaction effect between the 10-repeat (10R) allele of the dopamine transporter (DAT1) gene and the methionine (Met) allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism (F((1,1018)) = 11.11; P < 0.001). Carriers of the 9R/9R and the Val/Val genotype showed dramatically reduced Sadness scores in comparison to the other three genotype configurations. Both the 9R/9R and the Val/Val genotypes characterized by reduced transporter density and high dopamine catabolism, respectively, have been separately related to personality traits of PEM and externalizing behavior in the past. The present findings indicate that gene variations of the DA system previously associated with PEM are at the same time protective against high NEM and can therefore constitute a resilience factor against depression.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.