ArticlePediatric nephrology (Berlin, Germany)2012
Race-specific relationship of birth weight and renal function among healthy young children.
Article in Pediatric nephrology (Berlin, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Development and Evaluation of a Population Pharmacokinetic Model for High-Dose Methotrexate in Japanese Pediatric Patients with Acute Lymphoblastic Leukemia.Journal of clinical pharmacology · 2026Article
- Birth weight and renal markers in children aged 5-10 years in Cameroon: a cross-sectional study.BMC nephrology · 2020Article
- Prenatal pet keeping and caregiver-reported attention deficit hyperactivity disorder through preadolescence in a United States birth cohort.BMC pediatrics · 2019Article
- Risk of hypertension following perinatal adversity: IUGR and prematurity.The Journal of endocrinology · 2019Review
- In utero metal exposures measured in deciduous teeth and birth outcomes in a racially-diverse urban cohort.Environmental research · 2019Article
- Burden of higher lead exposure in African-Americans starts in utero and persists into childhood.Environment international · 2017Article
- Complications during pregnancy and fetal development: implications for the occurrence of chronic kidney disease.Expert review of cardiovascular therapy · 2017Review
- Article
- Detectable Blood Lead Level and Body Size in Early Childhood.Biological trace element research · 2016Article
- Race-specific Association of Caesarean-Section Delivery with Body Size at Age 2 Years.Ethnicity & disease · 2016Article
- Birth weight, malnutrition and kidney-associated outcomes--a global concern.Nature reviews. Nephrology · 2015Review
- Disparities, race/ethnicity and access to pediatric kidney transplantation.Current opinion in nephrology and hypertension · 2013Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundLow birth weight is associated with diminished renal function. However, despite African Americans being at increased risk of low birth weight and chronic kidney disease, little is known about the association between birth weight and renal function in diverse groups. We examined racial differences in the relationship of birth weight and renal function among healthy young children.
methodsBirth weight and serum creatinine data were available on 152 children (61.8% African American; 47.4% female) from a birth cohort. Estimated glomerular filtration rate (eGFR) was calculated using the bedside Schwartz equation and gender- and gestational-age-adjusted birth weight Z-scores using the US population as a reference. Race-specific linear regression models were fit to estimate the association between birth weight Z-score and eGFR.
resultsMean age was 1.5 ± 1.3 years at first eGFR measurement. African Americans had lower eGFR than non-African Americans (median eGFR = 82 vs. 95 ml/min per 1.73 m(2); p = 0.06). Birth weight was significantly and positively associated with eGFR among African American (p = 0.012) but not non-African American children (p = 0.33).
conclusionsWe provide, for the first time, evidence suggesting that birth weight is associated with renal function in African American children. Future work is needed to determine if prenatal programming helps explain racial disparities in adult health.
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