ArticleBrain and behavior2011
Comparison of weight changes following unilateral and staged bilateral STN DBS for advanced PD.
Article in Brain and behavior, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effect of deep brain stimulation on postoperative body mass index: A systematic review and meta-analysis.Neurosurgical review · 2024Pooled it
- Gender discrepancies and differences in motor and non-motor symptoms, cognition, and psychological outcomes in the treatment of Parkinson's disease with subthalamic deep brain stimulation.Frontiers in neurology · 2023Pooled it
- Deep Brain Stimulation of the Subthalamic Nucleus Modulates Reward-Related Behavior: A Systematic Review.Frontiers in human neuroscience · 2020Pooled it
- The Impact of Deep Brain Stimulation of the Subthalamic Nucleus on Sleep-Wake Function and Circadian Rhythms in Patients with Parkinson's Disease.Movement disorders clinical practice · 2025Article
- Unilateral and Bilateral Subthalamic Deep Brain Stimulation Differently Favour Apathy in Parkinson's Disease.The European journal of neuroscience · 2025Article
- Correlation of active contact location with weight gain after subthalamic nucleus deep brain stimulation: a case series.BMC neurology · 2021Article
- Adverse events associated with deep brain stimulation for movement disorders: analysis of 510 consecutive cases.Neurosurgery · 2015Article
- Mechanisms of body weight fluctuations in Parkinson's disease.Frontiers in neurology · 2014Review
- Weight change after globus pallidus internus or subthalamic nucleus deep brain stimulation in Parkinson's disease and dystonia.Stereotactic and functional neurosurgery · 2012Article
- Weight gain is associated with medial contact site of subthalamic stimulation in Parkinson's disease.PloS one · 2012Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unilateral and bilateral subthalamic nucleus deep brain stimulation (STN DBS) in Parkinson's disease (PD) result in weight gain in the initial postoperative months, but little is known about the changes in weight following unilateral and staged bilateral STN DBS over longer time intervals. A case-control comparison evaluated weight changes over 2 years in 43 consecutive unilateral STN DBS patients, among whom 25 elected to undergo staged bilateral STN DBS, and 21 age-matched and disease severity matched PD controls without DBS. Regression analyses incorporating age, gender, and baseline weight in case or control were conducted to assess weight changes 2 years after the initial unilateral surgery. Unilateral STN DBS and staged bilateral STN DBS patients gained 3.9 ± 2.0 kg and 5.6 ± 2.1 kg versus their preoperative baseline weight (P < 0.001, respectively) while PD controls without DBS lost 0.8 ± 1.1 kg. Although bilateral STN DBS patients gained 1.7 kg more than unilateral STN DBS patients at 2 years, this difference was not statistically significant (P = 0.885). Although there was a trend toward greater weight gain in staged bilateral STN DBS patients versus unilateral patients, we found no evidence for an equivalent or synergistic increase in body weight following placement of the second DBS electrode.
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