Trial reportEuropean journal of nuclear medicine and molecular imaging2012
Quantification of myocardial blood flow with 82Rb positron emission tomography: clinical validation with 15O-water.
Trial report in European journal of nuclear medicine and molecular imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.
- Radiopharmaceuticals for PET and SPECT Imaging: A Literature Review over the Last Decade.International journal of molecular sciences · 2022Pooled it
- Reliability of rubidium-82 PET/CT for renal perfusion determination in healthy subjects.BMC nephrology · 2022Trial
- Randomized Trial Comparing the Effects of Ticagrelor Versus Clopidogrel on Myocardial Perfusion in Patients With Coronary Artery Disease.Journal of the American Heart Association · 2017Trial
- Feasibility and operator variability of myocardial blood flow and reserve measurements with ⁹⁹mTc-sestamibi quantitative dynamic SPECT/CT imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Trial
- Establishing normal myocardial blood flow and myocardial flow reserve values: a rubidium-82 positron emission tomography study.European journal of nuclear medicine and molecular imaging · 2026Article
- Intra-Individual Variability of Myocardial Blood Flow and Flow Reserve Assessed by [Diagnostics (Basel, Switzerland) · 2026Article
- Fully automatic left ventricle segmentation in [Formula: see text]Rb PET/CT Using a semi-supervised nnU-net.EJNMMI research · 2026Article
- Patient-centric performance and interpretation of positron emission tomography /computed tomography myocardial perfusion imaging: a clinical consensus statement of the European Association of Cardiovascular Imaging of the European Society of Cardiology.European heart journal. Imaging methods and practice · 2026Review
- Biodistribution and radiation dosimetry ofEJNMMI research · 2025Article
- New horizons in nuclear cardiology: Imaging of peripheral arterial disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2025Review
- TAI-GAN: A Temporally and Anatomically Informed Generative Adversarial Network for early-to-late frame conversion in dynamic cardiac PET inter-frame motion correction.Medical image analysis · 2024Article
- Multi-modality imaging for assessment of the microcirculation in peripheral artery disease: Bench to clinical practice.American heart journal plus : cardiology research and practice · 2024Article
- Comparing various AI approaches to traditional quantitative assessment of the myocardial perfusion in [Scientific reports · 2024Article
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- TAI-GAN: Temporally and Anatomically Informed GAN for Early-to-Late Frame Conversion in Dynamic Cardiac PET Motion Correction.Simulation and synthesis in medical imaging : ... International Workshop, SASHIMI ..., held in conjunction with MICCAI ..., proceedings. SASHIMI (Workshop) · 2023Article
- Effect of temporal sampling protocols on myocardial blood flow measurements using Rubidium-82 PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Left ventricular ejection fraction, myocardial blood flow and hemodynamic variables in adenosine and regadenoson vasodilator 82-Rubidium PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Myocardial perfusion quantification with Rb-82 PET: good interobserver agreement of Carimas software on global, regional, and segmental levels.Annals of nuclear medicine · 2022Article
- Quantitative myocardial perfusionJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeQuantification of myocardial blood flow (MBF) with generator-produced (82)Rb is an attractive alternative for centres without an on-site cyclotron. Our aim was to validate (82)Rb-measured MBF in relation to that measured using (15)O-water, as a tracer 100% of which can be extracted from the circulation even at high flow rates, in healthy control subject and patients with mild coronary artery disease (CAD).
methodsMBF was measured at rest and during adenosine-induced hyperaemia with (82)Rb and (15)O-water PET in 33 participants (22 control subjects, aged 30 ± 13 years; 11 CAD patients without transmural infarction, aged 60 ± 13 years). A one-tissue compartment (82)Rb model with ventricular spillover correction was used. The (82)Rb flow-dependent extraction rate was derived from (15)O-water measurements in a subset of 11 control subjects. Myocardial flow reserve (MFR) was defined as the hyperaemic/rest MBF. Pearson's correlation r, Bland-Altman 95% limits of agreement (LoA), and Lin's concordance correlation ρ (c) (measuring both precision and accuracy) were used.
resultsOver the entire MBF range (0.66-4.7 ml/min/g), concordance was excellent for MBF (r = 0.90, [(82)Rb-(15)O-water] mean difference ± SD = 0.04 ± 0.66 ml/min/g, LoA = -1.26 to 1.33 ml/min/g, ρ(c) = 0.88) and MFR (range 1.79-5.81, r = 0.83, mean difference = 0.14 ± 0.58, LoA = -0.99 to 1.28, ρ(c) = 0.82). Hyperaemic MBF was reduced in CAD patients compared with the subset of 11 control subjects (2.53 ± 0.74 vs. 3.62 ± 0.68 ml/min/g, p = 0.002, for (15)O-water; 2.53 ± 1.01 vs. 3.82 ± 1.21 ml/min/g, p = 0.013, for (82)Rb) and this was paralleled by a lower MFR (2.65 ± 0.62 vs. 3.79 ± 0.98, p = 0.004, for (15)O-water; 2.85 ± 0.91 vs. 3.88 ± 0.91, p = 0.012, for (82)Rb). Myocardial perfusion was homogeneous in 1,114 of 1,122 segments (99.3%) and there were no differences in MBF among the coronary artery territories (p > 0.31).
conclusionQuantification of MBF with (82)Rb with a newly derived correction for the nonlinear extraction function was validated against MBF measured using (15)O-water in control subjects and patients with mild CAD, where it was found to be accurate at high flow rates. (82)Rb-derived MBF estimates seem robust for clinical research, advancing a step further towards its implementation in clinical routine.
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