Evidence map›Paper›PMID 22398931›Full record

ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2012

Three-dimensional patient setup errors at different treatment sites measured by the Tomotherapy megavoltage CT.

S K Hui, E Lusczek, T DeFor, K Dusenbery, S Levitt

Abstract read
In one paragraph

Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Article
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  4. Article
  5. Article
  6. Dose Escalation of Total Marrow Irradiation in High-Risk Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2017
    Article
  7. Article
  8. Article
  9. Article
  10. Quality of patient positioning during cerebral tomotherapy irradiation using different mask systems.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2014
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

S K HuiDepartment of Therapeutic Radiology - Radiation Oncology, University of Minnesota Medical School, 420 Delaware Street SE, Mayo Mail Code 494, 55455, Minneapolis, MN, USA. huixx019@umn.edu
E Lusczek
T DeFor
K Dusenbery
S Levitt

Funding

CALIFORNIA TEACHERS STUDYR01CA077398 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERNSTEIN, LESLIE · 1998 to 2014
$29.7M
Univ of Minnesota Buidling Interdisciplinary Research Careers in Women's HealthK12HD055887 · NICHD · UNIVERSITY OF MINNESOTA · PI ALLEN, SHARON S, BERGE, JERICA M · 2007 to 2023
$8.6M
Conformal Total Body and Marrow Irradiation for LeukemiaR01CA154491 · NCI · UNIVERSITY OF MINNESOTA · PI HUI, SUSANTA K, WONG, JEFFREY Y · 2011 to 2024
$5.0M
NCI NIH HHS R01 CA077398NCI NIH HHS R01 CA154491NICHD NIH HHS K12 HD055887
6 · The paper itself

Abstract

background and purposeReduction of interfraction setup uncertainty is vital for assuring the accuracy of conformal radiotherapy. We report a systematic study of setup error to assess patients' three-dimensional (3D) localization at various treatment sites. PATIENTS AND

methodsTomotherapy megavoltage CT (MVCT) images were scanned daily in 259 patients from 2005-2008. We analyzed 6,465 MVCT images to measure setup error for head and neck (H&N), chest/thorax, abdomen, prostate, legs, and total marrow irradiation (TMI). Statistical comparisons of the absolute displacements across sites and time were performed in rotation (R), lateral (x), craniocaudal (y), and vertical (z) directions.

resultsThe global systematic errors were measured to be less than 3 mm in each direction with increasing order of errors for different sites: H&N, prostate, chest, pelvis, spine, legs, and TMI. The differences in displacements in the x, y, and z directions, and 3D average displacement between treatment sites were significant (p < 0.01). Overall improvement in patient localization with time (after 3-4 treatment fractions) was observed. Large displacement (> 5 mm) was observed in the 75(th) percentile of the patient groups for chest, pelvis, legs, and spine in the x and y direction in the second week of the treatment.

conclusionMVCT imaging is essential for determining 3D setup error and to reduce uncertainty in localization at all anatomical locations. Setup error evaluation should be performed daily for all treatment regions, preferably for all treatment fractions.

Indexed as

Dose Fractionation, RadiationFemaleHumansImaging, Three-DimensionalMaleNeoplasmsOrgans at RiskPatient PositioningRadiotherapy, ConformalRadiotherapy, High-EnergyRadiotherapy Planning, Computer-AssistedRadiotherapy Setup ErrorsTomography, X-Ray ComputedUser-Computer Interface

Identifiers

PMID22398931
PMCPMC5689463

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.