ArticleParasitology research2012
Pseudocyst forms of Trichomonas vaginalis from cervical neoplasia.
Article in Parasitology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Human parasitic protozoan infection to infertility: a systematic review.Parasitology research · 2016Pooled it
- Diagnosis and Management of Trichomonas vaginalis: Summary of Evidence Reviewed for the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Trial
- Long-read transcriptomics corrects Trichomonas vaginalis intron annotations and refines transcript-end features.Parasites & vectors · 2026Article
- Article
- True cyst formation underlies persistence and drug tolerance in Tritrichomonas foetus.Nature communications · 2026Article
- Recent Advances in Biology, Host and Microbe Interactions of the Human Sexually Transmitted ParasiteInternational journal of molecular sciences · 2025Review
- Persistent Trichomonas vaginalis infections and the pseudocyst form.Trends in parasitology · 2023Review
- The correlation between Trichomonas vaginalis infection and reproductive system cancer: a systematic review and meta-analysis.Infectious agents and cancer · 2023Article
- Omics Analyses ofGenes · 2022Article
- Article
- Demonstration and Characterization of Cyst-Like Structures in the Life Cycle ofFrontiers in cellular and infection microbiology · 2019Article
- Detection of Pseudocyst Forms ofIranian journal of public health · 2018Article
- Trichinella spiralis and Tumors: Cause, Coincidence or Treatment?Anti-cancer agents in medicinal chemistry · 2018Review
- Morphologic study of the effect of iron on pseudocyst formation in Trichomonas vaginalis and its interaction with human epithelial cells.Memorias do Instituto Oswaldo Cruz · 2017Article
- Recombinant α-actinin subunit antigens of Trichomonas vaginalis as potential vaccine candidates in protecting against trichomoniasis.Parasites & vectors · 2017Article
- Reproductive Tract infections and Premalignant Lesions of Cervix: Evidence from Women Presenting at the Cancer Detection Centre of the Indian Cancer Society, Delhi, 2000-2012.Journal of obstetrics and gynaecology of India · 2016Article
- Trichomonas vaginalis: pathogenicity and potential role in human reproductive failure.Infection · 2016Review
- Trichomonas vaginalis: a review of epidemiologic, clinical and treatment issues.BMC infectious diseases · 2015Review
- Infection and cancer in multicellular organisms.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Biological roles of cysteine proteinases in the pathogenesis of Trichomonas vaginalis.Parasite (Paris, France) · 2014Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trichomonas vaginalis, a flagellated protozoan parasite causes a variety of adverse health consequences in both men and women. The parasite exists in the trophozoite and the pseudocystic stage. The study reports for the first time that pseudocyst forms of T. vaginalis isolated from cervical neoplasia (CN) patients demonstrated distinct, different and significant in vitro growth profiles when grown in vitro cultures from day 1 up to day 5 (p<0.05, Mann-Whitney test) when compared with the same life cycle stages isolated from non-cervical neoplasia but symptomatic patients (NCN). Pseudocysts from CN and NCN isolates remained viable in distilled water until 3 h 10 min and 2 h 10 min, respectively. The nucleus of pseudocysts in CN isolates using acridine orange and DAPI showed more intense staining revealing higher nuclear content. The FITC-labeled Concanavalin A stained stronger green fluorescence with surface of pseudocysts in CN isolates showing more rough and creased surface with higher numbers of deep micropores with larger numbers of chromatin masses, vacuoles, and hydrogenosomes. The study confirms that pseudocystic stage from CN, despite the uniformity in appearance of being rounded and showing no motility without a true cyst wall under light microscopy, demonstrated different biochemical, surface, and ultrastructural properties. The study provides evidence that phenotypic variant forms of pseudocysts does exist and possibly does play a role in exacerbating cervical cancer.
Indexed as
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22398830What OpenQuestion holds
Registered trials
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