ArticleInternational journal of colorectal disease2012
The effect of fibrin glue on the early healing phase of intestinal anastomoses in the rat.
Article in International journal of colorectal disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- The Effect of Albumin/Glutaraldehyde Glue (Bioglue) on Colonic Anastomosis Under Intestinal Obstruction: An Experimental Study in Rats.Journal of clinical medicine · 2025Article
- Trajectory of Self-Reported Pain and Association with Quality of Life in Patients with Perianal Abscesses After Surgery.Journal of pain research · 2025Article
- New understanding of gut microbiota and colorectal anastomosis leak: A collaborative review of the current concepts.Frontiers in cellular and infection microbiology · 2022Review
- Impact of tissue adhesives on the prevention of anastomotic leakage of colonic anastomoses: an in vivo study.International journal of colorectal disease · 2017Article
- The potential effect of biological sealants on colorectal anastomosis healing in experimental research involving severe diabetes.Annals of the Royal College of Surgeons of England · 2017Review
- International consensus statement regarding the use of animal models for research on anastomoses in the lower gastrointestinal tract.International journal of colorectal disease · 2016Article
- Colorectal anastomotic healing: why the biological processes that lead to anastomotic leakage should be revealed prior to conducting intervention studies.BMC gastroenterology · 2015Article
- Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive-a Laboratory and Clinical Perspective.ISRN surgery · 2014Review
- Fibrinogen and thrombin concentrations are critical for fibrin glue adherence in rat high-risk colon anastomoses.Clinics (Sao Paulo, Brazil) · 2014Article
- The effect of fibrin glue on the intensity of colonic anastomosis in the presence and absence of peritonitis: an experimental randomized controlled trial on rats.ISRN surgery · 2013Article
- Beneficiary Effect of Fibrin Glue on Healing of Ileoileal Anastomoses in Rats.In vivo (Athens, Greece)Article
- Fibrin glue and coats compromise the integrity of colonic anastomosis: an experimental trial on rats.Annals of gastroenterologyArticle
- The Effect of TISSEEL® on Colorectal Anastomosis Healing Process in a Diabetic Animal Experimental Model.In vivo (Athens, Greece)Article
- Our 20-year experience with experimental colonic anastomotic healing.Journal of medicine and lifeReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeProtecting the anastomotic integrity using suture or staple line reinforcement remains an important goal for ongoing research. The present comprehensive study aims to establish the effects of fibrin glue on the early phase of anastomotic healing in the rat intestine.
methodsOne hundred and eight young adult male Wistar rats underwent resection and anastomosis of both the ileum and colon. In half, fibrin glue was applied around the anastomoses. Parameters for repair included wound strength, both bursting pressure and breaking strength at days 1, 3, and 5 after operation; hydroxyproline content; and histology, the latter also after 7 days.
resultsA transient colonic ileus was observed in the experimental group. Anastomotic breaking strength was always similar in both the control and fibrin glue groups. Anastomotic bursting pressures remained low at days 1 and 3, without any differences between the groups. In both groups, the bursting pressure increased sharply (p < 0.001) between days 3 and 5. At day 5, the bursting pressure in the fibrin glue group remained below than that in the controls, although only significantly (p = 0.0138) so in the ileum. At day 5, but not at day 7, the wounds in the fibrin glue group contained less collagen. Other aspects of microscopic wound architecture appeared to be the same.
conclusionsThere is no justification for using fibrin glue on patent anastomoses constructed under low-risk conditions. Its potential benefit under conditions where chances for anastomotic leakage are enhanced needs further investigation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.