ArticleTrends in immunology2012
Pathogen-specific T cell depletion and reactivation of opportunistic pathogens in HIV infection.
Article in Trends in immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Immunological Determinants of Oncogenic Virus-Driven Cancers in Africa: Mechanisms, Co-Infections and Public Health Challenges.Pathogens (Basel, Switzerland) · 2026Review
- T-Cell Profiles in HBV Functional Cure and People Living With HIV: Known Knowns, Known Unknowns, and Unknown Unknowns.Current HIV/AIDS reports · 2026Review
- CD4+ Cytotoxic T Cells Involved in the Development of EBV-Associated Diseases.Pathogens (Basel, Switzerland) · 2022Review
- Phosphatidylcholine Liposomes Down-Modulate CD4 Expression Reducing HIV Entry in Human Type-1 Macrophages.Frontiers in immunology · 2022Article
- Contribution of Sex Differences to HIV Immunology, Pathogenesis, and Cure Approaches.Frontiers in immunology · 2022Review
- Antigen-driven clonal selection shapes the persistence of HIV-1-infected CD4+ T cells in vivo.The Journal of clinical investigation · 2021Article
- Depletion of Human Papilloma Virus E6- and E7-Oncoprotein-Specific T-Cell Responses in Women Living With HIV.Frontiers in immunology · 2021Article
- The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function.International journal of molecular sciences · 2020Article
- The Role of Dendritic Cells in TB and HIV Infection.Journal of clinical medicine · 2020Review
- Immune Phenotype and Functionality ofPathogens (Basel, Switzerland) · 2020Article
- The forces driving clonal expansion of the HIV-1 latent reservoir.Virology journal · 2020Review
- Endemic infection can shape exposure to novel pathogens: Pathogen co-occurrence networks in the Serengeti lions.Ecology letters · 2019Article
- Distinct susceptibility of HIV vaccine vector-induced CD4 T cells to HIV infection.PLoS pathogens · 2018Article
- Article
- Selective reduction of IFN-γ single positive mycobacteria-specific CD4+ T cells in HIV-1 infected individuals with latent tuberculosis infection.Tuberculosis (Edinburgh, Scotland) · 2016Article
- CD25+ FoxP3+ Memory CD4 T Cells Are Frequent Targets of HIV Infection In Vivo.Journal of virology · 2016Article
- HIV Susceptibility of human antigen-specific CD4 T cells in AIDS pathogenesis and vaccine response.Expert review of vaccines · 2016Review
- Sequential Dysfunction and Progressive Depletion of Candida albicans-Specific CD4 T Cell Response in HIV-1 Infection.PLoS pathogens · 2016Article
- A comparative phase 1 clinical trial to identify anti-infective mechanisms of vitamin D in people with HIV infection.AIDS (London, England) · 2015Article
- In search of a new paradigm for protective immunity to TB.Nature reviews. Microbiology · 2014Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
During HIV infection, it is unclear why different opportunistic pathogens cause disease at different CD4 T cell count thresholds. Early work has shown that CD4 T cell depletion is influenced both by cellular activation status and expression of viral entry receptors. More recently, functional characteristics of the CD4 T cells, such as cytokine and chemokine production, have also been shown to influence cellular susceptibility to HIV. Here, we examine how functional differences in pathogen-specific CD4 T cells could lead to their differential loss during HIV infection. This may have implications for when different opportunistic infections occur, and a better understanding of the mechanisms for functional imprinting of antigen-specific T cells may lead to improvements in design of vaccines against HIV and opportunistic pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.