ArticleCellular immunology2012
Homeostatic signals do not drive post-thymic T cell maturation.
Article in Cellular immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Recent Thymic Emigrants Require RBPJ-Dependent Notch Signaling to Transition into Functionally Mature Naive T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Cutting Edge: Glycolytic Metabolism and Mitochondrial Metabolism Are Uncoupled in Antigen-Activated CD8Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Reinterpreting recent thymic emigrant function: defective or adaptive?Current opinion in immunology · 2018Review
- Cutting Edge: Defective Aerobic Glycolysis Defines the Distinct Effector Function in Antigen-Activated CD8Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Dynamics of Recent Thymic Emigrants in Young Adult Mice.Frontiers in immunology · 2017Article
- Efforts of the human immune system to maintain the peripheral CD8+ T cell compartment after childhood thymectomy.Immunity & ageing : I & A · 2016Article
- Histone Deacetylase 3 Is Required for T Cell Maturation.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Immature recent thymic emigrants are eliminated by complement.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Impact of sepsis on CD4 T cell immunity.Journal of leukocyte biology · 2014Review
- Maturation and migration of murine CD4 single positive thymocytes and thymic emigrants.Computational and structural biotechnology journal · 2014Review
- T cells home to the thymus and control infection.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Maturation and emigration of single-positive thymocytes.Clinical & developmental immunology · 2013Review
- Homeostatic properties and phenotypic maturation of murine CD4+ pre-thymic emigrants in the thymus.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Recent thymic emigrants, the youngest T cells in the lymphoid periphery, undergo a 3 week-long period of functional and phenotypic maturation before being incorporated into the pool of mature, naïve T cells. Previous studies indicate that this maturation requires T cell exit from the thymus and access to secondary lymphoid organs, but is MHC-independent. We now show that post-thymic T cell maturation is independent of homeostatic and costimulatory pathways, requiring neither signals delivered by IL-7 nor CD80/86. Furthermore, while CCR7/CCL19,21-regulated homing of recent thymic emigrants to the T cell zones within the secondary lymphoid organs is not required for post-thymic T cell maturation, an intact dendritic cell compartment modulates this process. It is thus clear that, unlike T cell development and homeostasis, post-thymic maturation is focused not on interrogating the T cell receptor or the cell's responsiveness to homeostatic or costimulatory signals, but on some as yet unrecognized property.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.