ArticleJournal of virology2012
Structure of the Fab-labeled "breathing" state of native poliovirus.
Article in Journal of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed.
- Foot-and-mouth disease virus VP4 interferes with host interferon response by targeting the nuclear translocation of interferon regulatory factor 3 (IRF3).Veterinary research · 2026Article
- Cryo-EM structure of the Seneca Valley virus A-particle and related structural states.Journal of virology · 2025Article
- Cell entry and release of quasi-enveloped human hepatitis viruses.Nature reviews. Microbiology · 2023Review
- In silico epitope prediction and evolutionary analysis reveals capsid mutation patterns for enterovirus B.PloS one · 2023Article
- Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX.PLoS pathogens · 2022Article
- Thermal stabilization of enterovirus A 71 and production of antigenically stabilized empty capsids.The Journal of general virology · 2022Article
- Article
- Generation of Antibodies against Foot-and-Mouth-Disease Virus Capsid Protein VP4 Using Hepatitis B Core VLPs as a Scaffold.Life (Basel, Switzerland) · 2021Article
- Capsid opening enables genome release of iflaviruses.Science advances · 2021Article
- Cryo-EM structures reveal two distinct conformational states in a picornavirus cell entry intermediate.PLoS pathogens · 2020Article
- Physical virology: From virus self-assembly to particle mechanics.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2020Review
- Review
- Albumin Enhances the Rate at Which Coxsackievirus B3 Strain 28 Converts to A-Particles.Journal of virology · 2020Article
- Extracellular Albumin and Endosomal Ions Prime Enterovirus Particles for Uncoating That Can Be Prevented by Fatty Acid Saturation.Journal of virology · 2019Article
- Selection and Characterization of a Reovirus Mutant with Increased Thermostability.Journal of virology · 2019Article
- Structural basis for neutralization of hepatitis A virus informs a rational design of highly potent inhibitors.PLoS biology · 2019Article
- Identification and Characterization of a Poliovirus Capsid Mutant with Enhanced Thermal Stability.Journal of virology · 2019Article
- Poorly neutralizing polyclonal antibody in vitro against coxsackievirus A16 circulating strains can prevent a lethal challenge in vivo.Human vaccines & immunotherapeutics · 2018Article
- Unraveling the Motions behind Enterovirus 71 Uncoating.Biophysical journal · 2018Article
- Bacteria and bacterial envelope components enhance mammalian reovirus thermostability.PLoS pathogens · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
At 37°C, the structure of poliovirus is dynamic, and internal polypeptides VP4 and N terminus of VP1 (residues 1 to 53) externalize reversibly. An Fab fragment of a monospecific antibody, which binds to residues 39 to 55 of VP1, was utilized to locate the N termini of VP1 in native (160S) particles in this "breathing" state. Fab and virus were mixed and imaged via cryogenic electron microscopy. The resulting reconstruction showed the capsid expands similarly to the irreversibly altered cell entry intermediate (135S) particle, but the N terminus of VP1 is located near the 2-fold axes, instead of the "propeller tip" as in 135S particles.
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Registered trials
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