ArticleAmerican journal of physiology. Renal physiology2012
Novel role of NF-κB-p65 in antioxidant homeostasis in human kidney-2 cells.
Article in American journal of physiology. Renal physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
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- Phytochemicals targeting NF-κB signaling: Potential anti-cancer interventions.Journal of pharmaceutical analysis · 2022Review
- A standardized extract of Asparagus officinalis stem improves HSP70-mediated redox balance and cell functions in bovine cumulus-granulosa cells.Scientific reports · 2021Article
- Thiamine Alleviates High-Concentrate-Diet-Induced Oxidative Stress, Apoptosis, and Protects the Rumen Epithelial Barrier Function in Goats.Frontiers in veterinary science · 2021Article
- Protective Renal Effects of Atrial Natriuretic Peptide: Where Are We Now?Frontiers in physiology · 2021Review
- Increased renal oxidative stress in salt-sensitive human GRK4γ486V transgenic mice.Free radical biology & medicine · 2017Article
- Nrf2 Transcription Factor Can Directly Regulate mTOR: LINKING CYTOPROTECTIVE GENE EXPRESSION TO A MAJOR METABOLIC REGULATOR THAT GENERATES REDOX ACTIVITY.The Journal of biological chemistry · 2016Article
- Novel insights into redox system and the mechanism of redox regulation.Molecular biology reports · 2016Review
- Lysosomal cystine accumulation promotes mitochondrial depolarization and induction of redox-sensitive genes in human kidney proximal tubular cells.The Journal of physiology · 2016Article
- The role of transcription factor Nrf2 in skin cells metabolism.Archives of dermatological research · 2015Review
- Signaling pathways involved in renal oxidative injury: role of the vasoactive peptides and the renal dopaminergic system.Journal of signal transduction · 2014Review
- NFkB and Nrf2 in esophageal epithelial barrier function.Tissue barriers · 2013Article
- Renal dopamine receptors, oxidative stress, and hypertension.International journal of molecular sciences · 2013Review
- D5 dopamine receptor decreases NADPH oxidase, reactive oxygen species and blood pressure via heme oxygenase-1.Hypertension research : official journal of the Japanese Society of Hypertension · 2013Article
- Fenoldopam Mesylate Enhances the Survival of Mesenchymal Stem Cells Under Oxidative Stress and Increases the Therapeutic Function in Acute Kidney Injury.Cell transplantationArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Nuclear factor-κB (NF-κB) plays a role in inflammation. However, we recently reported an association between NF-κB and antioxidant enzymes in renal proximal tubules of exercise-trained rats, suggesting its role in antioxidant homeostasis (George L, Lokhandwala MF, Asghar M. Am J Physiol Renal Physiol 297: F1174-F1180, 2009). A direct role of NF-κB in antioxidant homeostasis in renal cells has not been elucidated and warrants investigation. Therefore, we examined whether NF-κB has a direct role in antioxidant homeostasis and redox balance in human kidney-2 cells overexpressing NF-κB-p65 and compared them with the cells overexpressing Nrf-2, a well-known transcription factor involved in antioxidant homeostasis. The ability of NF-κB-p65 to increase antioxidant enzymes, to reduce reactive oxygen species (ROS), and to rescue ROS-induced renal dopamine D1 receptor dysfunction, was studied. The transcription activity of NF-κB-p65 and Nrf-2, measured as luciferase reporter activity, increased in cells overexpressing these nuclear factors. The levels of mRNA and activity of glutathione peroxidase as well as the protein levels of superoxide dismutase-1 and glutamylcystein transferase were increased in cells overexpressing NF-κB-p65 and Nrf-2. Furthermore, the levels of ROS decreased and D1 receptor agonist SKF38393-mediated [(35)S]GTPγS binding (index of D1 receptor function) increased in the presence of hydrogen peroxide in cells overexpressing NF-κB-p65 and Nrf-2. These results suggest a direct role of NF-κB-p65 in antioxidant homeostasis, contributing to redox balance in renal cells.
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