ArticleBMC public health2012
Chewing areca nut increases the risk of coronary artery disease in Taiwanese men: a case-control study.
Article in BMC public health, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- An evolutionary perspective on the use of betel nut and its effects on health outcomes.Evolution, medicine, and public health · 2026Article
- Causes of death after oral cancer diagnosis: a population based study.Frontiers in oncology · 2024Article
- Article
- Betel-Quid Chewing, Heart Failure, and Premature Ventricular Contractions in Patients with Cardiopulmonary Symptoms.International journal of environmental research and public health · 2020Article
- Environmental tobacco smoke (ETS) and hyperlipidemia modified by perceived work stress.PloS one · 2020Article
- Areca nut chewing is associated with common mental disorders: a population-based study.Social psychiatry and psychiatric epidemiology · 2018Article
- Areca Nut Chewing and the Risk of Re-hospitalization and Mortality Among Patients With Acute Coronary Syndrome in Pakistan.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2018Article
- Relationship of Oxidative Stress, Inflammation, and the Risk of Metabolic Syndrome in Patients with Oral Cancer.Oxidative medicine and cellular longevity · 2018Article
- Article
- Areca Nut Chewing Complicated with Non-Obstructive and Obstructive ST Elevation Myocardial Infarction.Acta Cardiologica Sinica · 2016Article
- Observational
- Oral submucous fibrosis: an update.Clinical, cosmetic and investigational dermatology · 2015Review
- Association between betel quid chewing and carotid intima-media thickness in rural Bangladesh.International journal of epidemiology · 2014Article
- A review of the systemic adverse effects of areca nut or betel nut.Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology · 2014Review
- Betel nut usage is a major risk factor for coronary artery disease.Global journal of health science · 2013Article
- Alcohol, betel-nut and cigarette consumption are negatively associated with health promoting behaviors in Taiwan: a cross-sectional study.BMC public health · 2013Article
- Areca nut chewing and risk of atrial fibrillation in Taiwanese men: a nationwide ecological study.International journal of medical sciences · 2013Article
- The impact of estradiol and 1,25(OH)2D3 on metabolic syndrome in middle-aged Taiwanese males.PloS one · 2013Article
- Systemic and Local Effects Among Patients With Betel Quid-Related Oral Cancer.Technology in cancer research & treatmentReview
- Decoding the link associated with areca nut chewing and cardiovascular disease using hsCRP as a biomarker.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAreca nut chewing has been reported to be associated with obesity, metabolic syndrome, hypertension, and cardiovascular mortality in previous studies. The aim of this study was to examine whether chewing areca nut increases the risk of coronary artery disease (CAD) in Taiwanese men.
methodsThis study is a hospital-based case-control study. The case patients were male patients diagnosed in Taiwan between 1996 and 2009 as having a positive Treadmill exercise test or a positive finding on the Thallium-201 single-photon emission computed tomography myocardial perfusion imaging. The case patients were further evaluated by coronary angiography to confirm their CAD. Obstructive CAD was defined as a ≥ 50% decrease in the luminal diameter of one major coronary artery. The patients who did not fulfill the above criteria of obstructive CAD were excluded.The potential controls were males who visited the same hospital for health check-ups and had a normal electrocardiogram but no history of ischemic heart disease or CAD during the time period that the case patients were diagnosed. The eligible controls were randomly selected and frequency-matched with the case patients based on age. Multiple logistic regression analyses were used to estimate the odds ratio of areca nut chewing and the risk of obstructive CAD.
resultsA total of 293 obstructive CAD patients and 720 healthy controls, all men, were analyzed. Subjects who chewed areca nut had a 3.5-fold increased risk (95% CI = 2.0-6.2) of having obstructive CAD than those without, after adjusting for other significant covariates. The dose-response relationship of chewing areca nut and the risk of obstructive CAD was also noted. After adjusting for other covariates, the 2-way additive interactions for obstructive CAD risk were also significant between areca nut use and cigarette smoking, hypertension and dyslipidemia.
conclusionsLong-term areca nut chewing was an independent risk factor of obstructive CAD in Taiwanese men. Interactive effects between chewing areca nut and cigarette smoking, hypertension, and dyslipidemia were also observed for CAD risk. Further exploration of their underlying mechanisms is necessary.
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