Evidence map›Paper›PMID 22397486›Full record

ArticleAnalytical chemistry2012

In situ electrokinetic enhancement for self-assembled-monolayer-based electrochemical biosensing.

Mandy L Y Sin, Tingting Liu, Jeffrey D Pyne, Vincent Gau, Joseph C Liao, Pak Kin Wong

Abstract readEvaluation Study
In one paragraph

Article in Analytical chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Long-range electrothermal fluid motion in microfluidic systems.International journal of heat and mass transfer · 2016
    Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. A Universal Electrode Approach for Automated Electrochemical Molecular Analyses.Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems · 2013
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mandy L Y SinDepartment of Aerospace and Mechanical Engineering, University of Arizona, Tucson, Arizona 85721, United States.
Tingting Liu
Jeffrey D Pyne
Vincent Gau
Joseph C Liao
Pak Kin Wong

Funding

An Integrated Diagnostic Biochip for Point of Care Pathogen IdentificationU01AI082457 · NIAID · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI LIAO, JOSEPH C · 2009 to 2013
$3.7M
An Integrated Diagnostic System for Rapid Antimicrobial Susceptibility TestingR44AI088756 · NIAID · GENEFLUIDICS, INC. · PI GAU, VINCENT JEN-JR · 2012 to 2014
$3.0M
Mechanoregulation of Tissue MorphogenesisDP2OD007161 · OD · UNIVERSITY OF ARIZONA · PI WONG, PAK KIN · 2010 to 2010
$2.3M
Rapid Antimicrobial Susceptibility Test Cartridge for Resource-Limited SettingsR43AI088756 · NIAID · GENEFLUIDICS, INC. · PI GAU, VINCENT JEN-JR · 2010 to 2011
$700k
Rapid Antibiotic Susceptibility Testing for Neonatal Intensive UnitsR43HD065303 · NICHD · GENEFLUIDICS, INC. · PI GAU, VINCENT JEN-JR · 2010 to 2011
$434k
NIAID NIH HHS 1U01AI082457-01NIAID NIH HHS R43 AI088756NIAID NIH HHS R43AI088756-01NIAID NIH HHS R44 AI088756NIAID NIH HHS U01 AI082457NICHD NIH HHS R43 HD065303NICHD NIH HHS R43HD065303-01NIH HHS 1DP2OD007161-01NIH HHS DP2 OD007161
6 · The paper itself

Abstract

This study reports a multifunctional electrode approach which directly implements electrokinetic enhancement on a self-assembled-monolayer-based electrochemical sensor for point-of-care diagnostics. Using urinary tract infections as a model system, we demonstrate that electrokinetic enhancement, which involves in situ stirring and heating, can enhance the sensitivity of the strain specific 16S rRNA hybridization assay for 1 order of magnitude and accelerate the time-limiting incubation step with a 6-fold reduction in the incubation time. Since the same electrode platform is used for both electrochemical signal enhancement and electrochemical sensing, the multifunctional electrode approach provides a highly effective strategy toward fully integrated lab-on-a-chip systems for various biomedical applications.

Indexed as

Nucleic Acid HybridizationBacteriaBiosensing TechniquesElectrochemical TechniquesElectrodesEquipment DesignEscherichia coliHumansPseudomonas aeruginosaRNA, BacterialRNA, Ribosomal, 16SSensitivity and SpecificityStaphylococcus saprophyticusUrinary Tract InfectionsRNA, BacterialRNA, Ribosomal, 16S

Identifiers

PMID22397486
PMCPMC4069200

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.