ArticleJournal of the American Chemical Society2012
Single reporter for targeted multimodal in vivo imaging.
Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Failure to Thrive: Impaired BDNF Transport along the Cortical-Striatal Axis in Mouse Q140 Neurons of Huntington's Disease.Biology · 2023Article
- Radionuclide-based molecular imaging allows CAR-T cellular visualization and therapeutic monitoring.Theranostics · 2021Review
- Technologies and Standardization in Research on Extracellular Vesicles.Trends in biotechnology · 2020Review
- Membrane-bound Gaussia luciferase as a tool to track shedding of membrane proteins from the surface of extracellular vesicles.Scientific reports · 2019Article
- Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular Vesicles.Cell reports · 2019Article
- Review
- Imaging of anticancer drug action in single cells.Nature reviews. Cancer · 2017Review
- Periodic Mesoporous Organosilica Coated Prussian Blue for MR/PA Dual-Modal Imaging-Guided Photothermal-Chemotherapy of Triple Negative Breast Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2017Article
- Transferring intercellular signals and traits between cancer cells: extracellular vesicles as "homing pigeons".Cell communication and signaling : CCS · 2016Review
- Bioluminescence imaging in live cells and animals.Neurophotonics · 2016Article
- Development of Timd2 as a reporter gene for MRI.Magnetic resonance in medicine · 2016Article
- Single (19)F probe for simultaneous detection of multiple metal ions using miCEST MRI.Journal of the American Chemical Society · 2015Article
- Lanthanide probes for bioresponsive imaging.Chemical reviews · 2014Review
- Dynamic biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter.ACS nano · 2014Article
- Dual-modality gene reporter for in vivo imaging.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Noninvasive in vivo monitoring of extracellular vesicles.Methods in molecular biology (Clifton, N.J.) · 2014Article
- Camelid reporter gene imaging: a generic method for in vivo cell tracking.EJNMMI research · 2014Article
- Triple bioluminescence imaging for in vivo monitoring of cellular processes.Molecular therapy. Nucleic acids · 2013Article
- Tyrosinase as a multifunctional reporter gene for Photoacoustic/MRI/PET triple modality molecular imaging.Scientific reports · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
We have developed a multifaceted, highly specific reporter for multimodal in vivo imaging and applied it for detection of brain tumors. A metabolically biotinylated, membrane-bound form of Gaussia luciferase was synthesized, termed mbGluc-biotin. We engineered glioma cells to express this reporter and showed that brain tumor formation can be temporally imaged by bioluminescence following systemic administration of coelenterazine. Brain tumors expressing this reporter had high sensitivity for detection by magnetic resonance and fluorescence tomographic imaging upon injection of streptavidin conjugated to magnetic nanoparticles or fluorophore, respectively. Moreover, single photon emission computed tomography showed enhanced imaging of these tumors upon injection with streptavidin complexed to (111)In-DTPA-biotin. This work shows for the first time a single small reporter (∼40 kDa) which can be monitored with most available molecular imaging modalities and can be extended for single cell imaging using intravital microscopy, allowing real-time tracking of any cell expressing it in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.