ArticleAging and disease2011
Senescence-accelerated Mice (SAMs) as a Model for Brain Aging and Immunosenescence.
Article in Aging and disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Prebiotic raffinose attenuates surgery-induced delirium-like behaviors through gut microbiota-mediated serotonergic signaling in frail senescence-accelerated mice: an experimental study using SAMP10 mice.Journal of anesthesia · 2026Article
- Non-transgenic rodent models of Alzheimer's disease for preclinical research: a review.Molecular biology reports · 2025Review
- Article
- Immunophenotypes in psychosis: is it a premature inflamm-aging disorder?Molecular psychiatry · 2024Review
- Protective Effects of Fish (Alaska Pollock) Protein Intake against Short-Term Memory Decline in Senescence-Accelerated Mice.Nutrients · 2022Article
- Dasatinib plus quercetin attenuates some frailty characteristics in SAMP10 mice.Scientific reports · 2022Article
- A Neuroscience Primer for Integrating Geroscience With the Neurobiology of Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Novel genetic variants associated with brain functional networks in 18,445 adults from the UK Biobank.Scientific reports · 2021Article
- RNA-seq and miRNA-seq data from pharmacological inhibition of the G9a/GLP histone methyltransferase complex with UNC0642 in SAMP8 mice.Data in brief · 2021Article
- Improving Age-Related Cognitive Decline through Dietary Interventions Targeting Mitochondrial Dysfunction.International journal of molecular sciences · 2021Review
- Senescent accelerated prone 8 (SAMP8) mice as a model of age dependent neuroinflammation.Journal of neuroinflammation · 2021Article
- Amelioration of Alzheimer's disease pathology and cognitive deficits by immunomodulatory agents in animal models of Alzheimer's disease.Neural regeneration research · 2019Article
- Resveratrol Boosts Cognitive Function by Targeting SIRT1.Neurochemical research · 2018Review
- Blood brain barrier permeability of (-)-epigallocatechin gallate, its proliferation-enhancing activity of human neuroblastoma SH-SY5Y cells, and its preventive effect on age-related cognitive dysfunction in mice.Biochemistry and biophysics reports · 2017Article
- Immune Dysfunction Associated with Abnormal Bone Marrow-Derived Mesenchymal Stroma Cells in Senescence Accelerated Mice.International journal of molecular sciences · 2016Article
- Disparate Changes in Plasma and Brainstem Cytokine Levels in Adult and Ageing Rats Associated with Age-Related Changes in Facial Motor Neuron Number, Snout Muscle Morphology, and Exploratory Behavior.Frontiers in neurology · 2016Article
- Are Anxiety Disorders Associated with Accelerated Aging? A Focus on Neuroprogression.Neural plasticity · 2016Review
- Parkinson's disease as a result of aging.Aging cell · 2015Review
- Involvement of oxidative stress in SAMP10 mice with age-related neurodegeneration.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015Article
- What we can learn from animal models about cerebral multi-morbidity.Alzheimer's research & therapy · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Senescence-Accelerated Mouse (SAM) represents a group of inbred mouse strains developed as a model for the study of human aging and age-related diseases. Senescence-prone (SAMP) strains exhibit an early onset of age-related decline in the peripheral immunity such as thymic involution, loss of CD4(+) T cells, impaired helper T cell function, decreased antibody-forming capacity, dysfunction of antigen-presenting cells, decreased natural killer activity, increased auto-antibodies, and susceptibility to virus infection. Senescence-prone SAMP10 mice undergo age-related changes in the brain such as brain atrophy, shrinkage and loss of cortical neurons, retraction of cortical neuronal dendrites, loss of dendritic spines, loss of synapses, impaired learning and memory, depressive behavior, accumulation of neuronal DNA damage, neuronal ubiquitinated inclusions, reduced hippocampal cholinergic receptors, decreased neurotrophic factors, decreased hippocampal zinc and zinc transporters, increased sphyngomyelinase, and elevated oxidative-nitrative stress. Recent data indicating increased pro-inflammatory cytokines in the brain of SAMP10 mice are directing investigators toward an integration of immune and neural abnormalities to enhance understanding of the principles of brain aging. We highlight how mouse brain cells adopt cytokine-mediated responses and how SAMP10 mice are defective in these responses. SAMP10 model would be useful to study how age-related disturbances in peripheral immunity have an impact on dysregulation of brain tissue homeostasis, resulting in age-related neurodegeneration.
Indexed as
Identifiers
22396891PMC3295080W1747888350What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.