ArticleAging and disease2011
Age-related Dysregulation of Inflammation and Innate Immunity: Lessons Learned from Rodent Models.
Article in Aging and disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- A Comparison of Neutrophil Secretion of Cytokines and NET Formation in Response to Lipopolysaccharide and Group BJournal of inflammation research · 2026Article
- The role of inflammation induced by necroptosis in the development of fibrosis and liver cancer in novel knockin mouse models fed a western diet.GeroScience · 2025Article
- HMGB1/TLR4 signaling pathway enhances abdominal aortic aneurysm progression in mice by upregulating necroptosis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Article
- Article
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- Mechanistic inferences from clinical reports of SARS-CoV-2.Infectious diseases (London, England) · 2020Review
- Aging aggravated liver ischemia and reperfusion injury by promoting hepatocyte necroptosis in an endoplasmic reticulum stress-dependent manner.Annals of translational medicine · 2020Article
- The Inflammasome Adaptor Protein ASC in Mild Cognitive Impairment and Alzheimer's Disease.International journal of molecular sciences · 2020Article
- Free Fatty Acid Receptor 1 Signaling Contributes to Migration, MMP-9 Activity, and Expression of IL-8 Induced by Linoleic Acid in HaCaT Cells.Frontiers in pharmacology · 2020Article
- The Neutrophil: Constant Defender and First Responder.Frontiers in immunology · 2020Review
- Yolkin Isolated from Hen Egg Yolk as a Natural Immunoregulator, Activating Innate Immune Response in BMDM Macrophages.Oxidative medicine and cellular longevity · 2020Article
- Severe systemic inflammatory response syndrome in patients following Total aortic arch replacement with deep hypothermic circulatory arrest.Journal of cardiothoracic surgery · 2019Article
- The potential role of necroptosis in inflammaging and aging.GeroScience · 2019Review
- The Role of Pulmonary and Systemic Immunosenescence in Acute Lung Injury.Aging and disease · 2018Article
- Chronic Alterations in Systemic Immune Function after Traumatic Brain Injury.Journal of neurotrauma · 2018Article
- Contribution of the inflammasome to inflammaging.Journal of inflammation (London, England) · 2018Article
- Lycium Barbarum: A Traditional Chinese Herb and A Promising Anti-Aging Agent.Aging and disease · 2017Review
- Roburic Acid Suppresses NO and IL-6 Production via Targeting NF-κB and MAPK Pathway in RAW264.7 Cells.Inflammation · 2017Article
- Alcohol, aging, and innate immunity.Journal of leukocyte biology · 2017Review
- Advanced Age Alters Monocyte and Macrophage Responses.Antioxidants & redox signaling · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
In the elderly patient population, it has become increasingly evident that immune dysregulation is a contributing factor to age-related pathologies and their associated morbidity and mortality. In particular, elderly subjects are plagued by poor responses to infectious challenge and immunization and are at heightened risk for the development of autoimmune, neuroinflammatory and tumor-associated pathologies. Rodent models of aging and age-related disorders have been utilized to better describe how innate immune cell dysfunction contributes to these clinical scenarios. As the elderly population continues to increase in size, use of these aging rodent models to study immune dysregulation may translate into increased healthy living years for these individuals.
Indexed as
Identifiers
22396887PMC3295081What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.