ArticleAging and disease2011
Why do hair cells and spiral ganglion neurons in the cochlea die during aging?
Article in Aging and disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement.Life medicine · 2025Article
- Association between genetic risk and adherence to healthy lifestyle for developing age-related hearing loss.BMC medicine · 2024Article
- Cocoa Polyphenols Prevent Age-Related Hearing Loss and Frailty in an In Vivo Model.Antioxidants (Basel, Switzerland) · 2023Article
- Frequency and Time Domain Analysis of EEG Based Auditory Evoked Potentials to Detect Binaural Hearing in Noise.Journal of clinical medicine · 2023Article
- Na/K-ATPase Gene Expression in the Human Cochlea: A Study Using mRNAFrontiers in molecular neuroscience · 2022Article
- The effects of aging on peripheral and central auditory function in adults with normal hearing.American journal of translational research · 2021Article
- Suppressed expression of LDHB promotes age-related hearing loss via aerobic glycolysis.Cell death & disease · 2020Article
- Protective Effects of Silymarin Against Age-Related Hearing Loss in an Aging Rat Model.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2019Article
- Music and Noise: Same or Different? What Our Body Tells Us.Frontiers in psychology · 2019Review
- Otoprotective Effects of Stephania tetrandra S. Moore Herb Isolate against Acoustic Trauma.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
- MicroRNAs and Presbycusis.Aging and disease · 2018Review
- Effects of Ageing on the Mitochondrial Genome in Rat Vestibular Organs.Current aging science · 2018Article
- Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea.Neuroscience · 2017Article
- Biological therapies in otology.HNO · 2017Review
- Human Cochlear Histopathology Reflects Clinical Signatures of Primary Neural Degeneration.Scientific reports · 2017Article
- Article
- The brain, sirtuins, and ageing.Nature reviews. Neuroscience · 2017Review
- Role of antioxidants in prevention of age-related hearing loss: a review of literature.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Review
- Article
- Large-Scale Analysis of Auditory Segregation Behavior Crowdsourced via a Smartphone App.PloS one · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Age-related decline of cochlear function is mainly due to the loss of hair cells and spiral ganglion neurons (SGNs). Recent findings clearly indicate that survival of these two cell types during aging depends on genetic and environmental interactions, and this relationship is seen at the systemic, tissue, cellular, and molecular levels. At cellular and molecular levels, age-related loss of hair cells and SGNs can occur independently, suggesting distinct mechanisms for the death of each during aging. This mechanistic independence is also observed in the loss of medial olivocochlear efferent innervation and outer hair cells during aging, pointing to a universal independent cellular mechanism for age-related neuronal death in the peripheral auditory system. While several molecular signaling pathways are implicated in the age-related loss of hair cells and SGNs, studies with the ability to locally modify gene expression in these cell types are needed to address whether these signaling pathways have direct effects on hair cells and SGNs during aging. Finally, the issue of whether age-related loss of these cells occurs via typical apoptotic pathways requires further examination. As new studies in the field of aging reshape the framework for exploring these underpinnings, understanding of the loss of hair cells and SGNs associated with age and the interventions that can treat and prevent these changes will result in dramatic benefits for an aging population.
Indexed as
Identifiers
22396875PMC3295057W1554022145What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.