ArticleAging and disease2011
Aging and stress: past hypotheses, present approaches and perspectives.
Article in Aging and disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- Translational studies in older men using testosterone to treat sarcopenia.Transactions of the American Clinical and Climatological Association · 2014Trial
- Accelerated brain aging in Veterans with posttraumatic stress symptoms and mild traumatic brain injury.Neuroimage. Reports · 2026Article
- Attitudes Towards Aging, Depression, Physical Functioning, and Pain Among Women Living with HIV of Reproductive Age.AIDS and behavior · 2025Article
- Exploring Interindividual Variability in Resilience to Stress: Social Support, Coping Styles, and Diurnal Cortisol in Older Adults.Behavioral sciences (Basel, Switzerland) · 2025Article
- The effort hypothesis at the heart of the virtuous circle.EXCLI journal · 2025Review
- Chronic stress-induced anxiety-like behavior, hippocampal oxidative, and endoplasmic reticulum stress are reversed by young plasma transfusion in aged adult rats.Iranian journal of basic medical sciences · 2024Article
- Observational
- Vulnerability to chronic stress and the phenotypic heterogeneity of presbycusis with subjective tinnitus.Frontiers in neuroscience · 2022Review
- A Review of Minority Stress as a Risk Factor for Cognitive Decline in Lesbian, Gay, Bisexual, and Transgender (LGBT) Elders.Journal of gay & lesbian mental health · 2020Article
- Adrenal Aging and Its Implications on Stress Responsiveness in Humans.Frontiers in endocrinology · 2019Review
- Behavioral and Biochemical Impact of Chronic Unpredictable Mild Stress on the Acquisition of Nicotine Conditioned Place Preference in Rats.Molecular neurobiology · 2018Article
- Environmental Enrichment as a Positive Behavioral Intervention Across the Lifespan.Current neuropharmacology · 2017Review
- Aging-Associated Changes to Intrinsic Neuronal Excitability in the Bed Nucleus of the Stria Terminalis Is Cell Type-Dependent.Frontiers in aging neuroscience · 2017Article
- Novel concepts on pregnancy clocks and alarms: redundancy and synergy in human parturition.Human reproduction update · 2016Review
- Phenotypic and Molecular Evidence Suggests That Decrements in Morning and Evening Energy Are Distinct but Related Symptoms.Journal of pain and symptom management · 2015Article
- Dietary intake alters behavioral recovery and gene expression profiles in the brain of juvenile rats that have experienced a concussion.Frontiers in behavioral neuroscience · 2015Article
- Adrenocortical status predicts the degree of age-related deficits in prefrontal structural plasticity and working memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- A pleasant familiar odor influences perceived stress and peripheral nervous system activity during normal aging.Frontiers in psychology · 2014Article
- Human growth is associated with distinct patterns of gene expression in evolutionarily conserved networks.BMC genomics · 2013Article
- PPARγ and stress: implications for aging.Experimental gerontology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain aging has been suggested to be conditioned by an excessive glucocortioid secretion leading to damages on brain areas involved not only in cognitive and emotional processes but also in the control of the activity of the hypothalamic-pituitary adrenal axis. This review describes some of the hypothesis that try to explain the relation between the dysregulation of the stress response and brain aging, focusing on corticosterone but also on neurotransmission in the hippocampus, the prefrontal cortex and the amygdala. Moreover, different molecular factors can account for an enhanced vulnerability of the aged brain to stress exposure, specially for resilience. Among them, good candidates could be those mechanisms determining the levels of corticosterone in the brain, several molecules downstream glucocorticoid receptor activation (ie: heat shock proteins, BAG-1) or even the epigenetic programming of the HPA axis in early stages. In conclusion, genetic and environmental factors (early life stress, chronic stress during adulthood) can produce an enhanced vulnerability and a reduced resilience of the brain to subsequent stress exposures or to metabolic challenges leading, in turn, to an unsuccessful aging of the brain. However, results obtained with the use of the environmental enrichment model in animals, added to several results in humans also described in this review suggest that positive environmental factors (cognitive-demanding tasks or physical exercise) can help to maintain neuronal plasticity during aging and to protect the brain against the damaging effects of stress exposure.
Indexed as
Identifiers
22396868PMC3295041W1584501746What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.