ArticlePloS one2012
Flavonoid glycosides isolated from unique legume plant extracts as novel inhibitors of xanthine oxidase.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 80 citations in OpenAlex.
- Phytochemistry and Wound-Healing, Enzyme-Inhibitory, and Antifungal Activities of the Wild Forage LegumePlants (Basel, Switzerland) · 2026Article
- Flavonol glycosides accumulation in faba bean grown under combined selenium and sulfur application.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Antioxidant Metabolism Pathways in Vitamins, Polyphenols, and Selenium: Parallels and Divergences.International journal of molecular sciences · 2024Review
- A xanthine oxidase inhibit activity component from biotransformation of cholesterol byHeliyon · 2023Review
- Elucidation of chemical profiles and molecular targets of Mondia whitei leave fractions bioactive as novel therapeutics: an in vitro and in silico assay.Journal, genetic engineering & biotechnology · 2022Article
- Anti-Inflammatory and Hypouricemic Effect of Bioactive Compounds: Molecular Evidence and Potential Application in the Management of Gout.Current issues in molecular biology · 2022Review
- Current Research of Phytochemical, Medicinal and Non-Medicinal Uses ofMolecules (Basel, Switzerland) · 2022Review
- Phytochemical Profiling of the Leaf Extract ofOxidative medicine and cellular longevity · 2022Article
- Phenolic Profiles of Ten Australian Faba Bean Varieties.Molecules (Basel, Switzerland) · 2021Article
- Metabolites of Procyanidins FromFrontiers in nutrition · 2021Article
- Cross-sectional association between non-soy legume consumption, serum uric acid and hyperuricemia: the PREDIMED-Plus study.European journal of nutrition · 2020Article
- Isolation and Identification of F Lavonol Glycosides fromIranian journal of pharmaceutical research : IJPR · 2020Article
- Gender-Specific Inverse Associations Between Beans Intake, Serum Urate Levels, and Hyperuricemia: A Cross-Sectional Analysis Based on the Henan Rural Cohort Study.Frontiers in nutrition · 2020Article
- Effect ofMedicina (Kaunas, Lithuania) · 2019Article
- Isolation of Tricin as a Xanthine Oxidase Inhibitor from Sweet White Clover (Molecules (Basel, Switzerland) · 2018Article
- Antiradical and Xanthine Oxidase Inhibitory Activity Evaluations ofAntioxidants (Basel, Switzerland) · 2018Article
- Single Dose Administration of Taheebo Polyphenol Enhances Endurance Capacity in Mice.Scientific reports · 2018Article
- Flavonoids as a Natural Treatment AgainstFrontiers in cellular and infection microbiology · 2018Review
- Assessment of the antioxidant activity of an olive oil total polyphenolic fraction and hydroxytyrosol from a Greek Olea europea variety in endothelial cells and myoblasts.International journal of molecular medicine · 2017Article
- Effect of total flavonoids of Spatholobus suberectus Dunn on PCV2 induced oxidative stress in RAW264.7 cells.BMC complementary and alternative medicine · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Legumes and the polyphenolic compounds present in them have gained a lot of interest due to their beneficial health implications. Dietary polyphenolic compounds, especially flavonoids, exert antioxidant properties and are potent inhibitors of xanthine oxidase (XO) activity. XO is the main contributor of free radicals during exercise but it is also involved in pathogenesis of several diseases such as vascular disorders, cancer and gout. In order to discover new natural, dietary XO inhibitors, some polyphenolic fractions and pure compounds isolated from two legume plant extracts were tested for their effects on XO activity. The fractions isolated from both Vicia faba and Lotus edulis plant extracts were potent inhibitors of XO with IC(50) values range from 40-135 µg/mL and 55-260 µg/mL, respectively. All the pure polyphenolic compounds inhibited XO and their K(i) values ranged from 13-767 µM. Ten of the compounds followed the non competitive inhibitory model whereas one of them was a competitive inhibitor. These findings indicate that flavonoid isolates from legume plant extracts are novel, natural XO inhibitors. Their mode of action is under investigation in order to examine their potential in drug design for diseases related to overwhelming XO action.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.