ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Local dendrodendritic inhibition regulates fast synaptic transmission in visual thalamus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Local thalamic interneurons drive spindle termination and enable sleep-dependent learning.bioRxiv : the preprint server for biology · 2025Article
- Individual thalamic inhibitory interneurons are functionally specialized toward distinct visual features.Neuron · 2024Article
- The type of inhibition provided by thalamic interneurons alters the input selectivity of thalamocortical neurons.Current research in neurobiology · 2024Article
- A mechanism for deviance detection and contextual routing in the thalamus: a review and theoretical proposal.Frontiers in neuroscience · 2024Article
- AMIGO1 Promotes Axon Growth and Territory Matching in the Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- From Receptive to Perceptive Fields: Size-Dependent Asymmetries in Both Negative Afterimages and Subcortical On and Off Post-Stimulus Responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- An Individual Interneuron Participates in Many Kinds of Inhibition and Innervates Much of the Mouse Visual Thalamus.Neuron · 2020Article
- T-type calcium channels in synaptic plasticity.Channels (Austin, Tex.) · 2017Review
- The functional logic of corticostriatal connections.Brain structure & function · 2017Review
- Distinct kinetics of inhibitory currents in thalamocortical neurons that arise from dendritic or axonal origin.PloS one · 2017Article
- Biophysical Network Modelling of the dLGN Circuit: Different Effects of Triadic and Axonal Inhibition on Visual Responses of Relay Cells.PLoS computational biology · 2016Article
- Complex regulation of dendritic transmitter release from thalamic interneurons.Current opinion in neurobiology · 2014Review
- Patch clamp electrophysiology and capillary electrophoresis-mass spectrometry metabolomics for single cell characterization.Analytical chemistry · 2014Article
- Interneurons in the mouse visual thalamus maintain a high degree of retinal convergence throughout postnatal development.Neural development · 2013Article
- Thalamic microcircuits: presynaptic dendrites form two feedforward inhibitory pathways in thalamus.Journal of neurophysiology · 2013Article
- Metabotropic glutamate receptors drive global persistent inhibition in the visual thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Dynamics of intrinsic dendritic calcium signaling during tonic firing of thalamic reticular neurons.PloS one · 2013Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Inhibition from thalamic interneurons plays a critical role in modulating information transfer between thalamus and neocortex. Interestingly, these neurons yield inhibition via two distinct outputs: presynaptic dendrites that innervate thalamocortical relay neurons and axonal outputs. Since the dendrites of thalamic interneurons are the primary targets of incoming synaptic information, it has been hypothesized that local synaptic input could produce highly focused dendritic output. To gain additional insight into the computational power of these presynaptic dendrites, we have combined two-photon laser scanning microscopy, glutamate uncaging, and whole-cell electrophysiological recordings to locally activate dendritic terminals and study their inhibitory contribution to rat thalamocortical relay neurons. Our findings demonstrate that local dendritic release from thalamic interneurons is controlled locally by AMPA/NMDA receptor-mediated recruitment of L-type calcium channels. Moreover, by mapping these connections with single dendrite resolution we not only found that presynaptic dendrites preferentially target proximal regions, but such actions differ significantly across branches. Furthermore, local stimulation of interneuron dendrites did not result in global excitation, supporting the notion that these interneurons can operate as multiplexors, containing numerous independently operating input-output devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.