Evidence map›Paper›PMID 22396403›Full record

Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2012

Deliberation in the motor system: reflex gains track evolving evidence leading to a decision.

Luc P J Selen, Michael N Shadlen, Daniel M Wolpert

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed.

  1. Continuous track paths reveal additive evidence integration in multistep decision making.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Trial
  2. Trial
  3. Stretch-Induced Muscle Responses Under Threat Versus Safety.The European journal of neuroscience · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. The Trembling Hand Unraveled: Motor Dynamics and Choice Inconsistency.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  14. Online Movements Reflect Ongoing Deliberation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  15. Article
  16. Article
  17. Where does the processing of size meet the processing of space?Attention, perception & psychophysics · 2025
    Article
  18. Article
  19. Article
  20. Sensorimotor faculties bias choice behavior.Frontiers in psychology · 2025
    Article

50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Luc P J SelenComputational and Biological Learning Laboratory, Department of Engineering, University of Cambridge, Cambridge CB2 1PZ, UK. L.selen@donders.ru.nl
Michael N Shadlen
Daniel M Wolpert

Funding

YILMA SIV VACCINIA VACCINE TRIALP51RR000166 · NCRR · UNIVERSITY OF WASHINGTON · PI CHAMBERLAIN, JEFFREY S · 1985 to 2011
$161.1M
NEURAL MECHANISMS OF VISUAL PERCEPTIONR01EY011378 · NEI · UNIVERSITY OF WASHINGTON · PI SHADLEN, MICHAEL NEIL · 1996 to 2017
$3.8M
Howard Hughes Medical InstituteNCRR NIH HHS P51 RR000166NCRR NIH HHS RR00166NEI NIH HHS EY11378NEI NIH HHS R01 EY011378Wellcome Trust 077730
6 · The paper itself

Abstract

Both decision making and sensorimotor control require real-time processing of noisy information streams. Historically these processes were thought to operate sequentially: cognitive processing leads to a decision, and the outcome is passed to the motor system to be converted into action. Recently, it has been suggested that the decision process may provide a continuous flow of information to the motor system, allowing it to prepare in a graded fashion for the probable outcome. Such continuous flow is supported by electrophysiology in nonhuman primates. Here we provide direct evidence for the continuous flow of an evolving decision variable to the motor system in humans. Subjects viewed a dynamic random dot display and were asked to indicate their decision about direction by moving a handle to one of two targets. We probed the state of the motor system by perturbing the arm at random times during decision formation. Reflex gains were modulated by the strength and duration of motion, reflecting the accumulated evidence in support of the evolving decision. The magnitude and variance of these gains tracked a decision variable that explained the subject's decision accuracy. The findings support a continuous process linking the evolving computations associated with decision making and sensorimotor control.

Indexed as

AdultDecision MakingElectromyographyFemaleHumansMaleMotion PerceptionPhotic StimulationPsychomotor PerformanceReaction TimeReflexYoung Adult

Identifiers

PMID22396403
PMCPMC3299561

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.