ArticleDiabetes2012
Short-term hyperinsulinemia and hyperglycemia increase myocardial lipid content in normal subjects.
Article in Diabetes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 56 citations in OpenAlex.
- Reduced hepatocellular lipid accumulation and energy metabolism in patients with long standing type 1 diabetes mellitus.Scientific reports · 2019Trial
- Diabetes and cancer: therapeutic implications.Cardio-oncology (London, England) · 2026Review
- Retinol-binding protein 4 in cardiovascular diseases: mechanisms and therapeutic perspectives.Frontiers in cardiovascular medicine · 2026Review
- MicroRNA: unveiling novel mechanistic and theranostic pathways in diabetic cardiomyopathy.Frontiers in pharmacology · 2025Review
- Sex differences in ectopic lipid deposits and cardiac function across a wide range of glycemic control: a secondary analysis.Obesity (Silver Spring, Md.) · 2024Article
- Myocardial steatosis across the spectrum of human health and disease.Experimental physiology · 2024Review
- Olive Oil's Attenuating Effects on Lipotoxicity.Advances in experimental medicine and biology · 2024Review
- Osteoblast-intrinsic defect in glucose metabolism impairs bone formation in type II diabetic male mice.eLife · 2023Article
- DPP4 Activity, Hyperinsulinemia, and Atherosclerosis.The Journal of clinical endocrinology and metabolism · 2021Review
- Asymptomatic type 2 diabetes mellitus display a reduced myocardial deformation but adequate response during exercise.European journal of applied physiology · 2021Article
- Fisetin protects against streptozotocin-induced diabetic cardiomyopathy in rats by suppressing fatty acid oxidation and inhibiting protein kinase R.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2021Article
- Nuclear miR-320 Mediates Diabetes-Induced Cardiac Dysfunction by Activating Transcription of Fatty Acid Metabolic Genes to Cause Lipotoxicity in the Heart.Circulation research · 2019Article
- Insulin Resistance and Atherosclerosis: Implications for Insulin-Sensitizing Agents.Endocrine reviews · 2019Review
- Heart, lipids and hormones.Endocrine connections · 2017Review
- Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2.Nature communications · 2017Article
- Article
- Abnormal Myocardial Function Is Related to Myocardial Steatosis and Diffuse Myocardial Fibrosis in HIV-Infected Adults.The Journal of infectious diseases · 2015Article
- The Use of SGLT-2 Inhibitors in Type 2 Diabetes and Heart Failure.Metabolic syndrome and related disorders · 2015Review
- Myocardial Fat Accumulation Is Independent of Measures of Insulin Sensitivity.The Journal of clinical endocrinology and metabolism · 2015Article
- Insulin resistance as a physiological defense against metabolic stress: implications for the management of subsets of type 2 diabetes.Diabetes · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased myocardial lipid content (MYCL) recently has been linked to the development of cardiomyopathy in diabetes. In contrast to steatosis in skeletal muscle and liver, previous investigations could not confirm a link between MYCL and insulin resistance. Thus, we hypothesized that cardiac steatosis might develop against the background of the metabolic environment typical for prediabetes and early type 2 diabetes: combined hyperglycemia and hyperinsulinemia. Therefore, we aimed to prove the principle that acute hyperglycemia (during a 6-h clamp) affects MYCL and function (assessed by (1)H magnetic resonance spectroscopy and imaging) in healthy subjects (female subjects: n = 8, male subjects: n = 10; aged 28 ± 5 years; BMI 22.4 ± 2.6 kg/m(2)). Combined hyperglycemia (202.0 ± 10.6 mg/dL) and hyperinsulinemia (110.6 ± 59.0 μU/mL) were, despite insulin-mediated suppression of free fatty acids, associated with a 34.4% increase in MYCL (baseline: 0.20 ± 0.17%, clamp: 0.26 ± 0.22% of water signal; P = 0.0009), which was positively correlated with the area under the curve of insulin (R = 0.59, P = 0.009) and C-peptide (R = 0.81, P < 0.0001) during the clamp. Furthermore, an increase in ejection fraction (P < 0.0001) and a decrease in end-systolic volume (P = 0.0002) were observed, which also were correlated with hyperinsulinemia. Based on our findings, we conclude that combined hyperglycemia and hyperinsulinemia induce short-term myocardial lipid accumulation and alterations in myocardial function in normal subjects, indicating that these alterations might be directly responsible for cardiac steatosis in metabolic diseases.
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